Treatment of infection in burns

Gallagher, James J.; Williams‐Bouyer, Natalie; Villarreal, Cynthia; Heggers, John P.; Herndon, David N.

doi:10.1016/b978-1-4160-3274-8.50015-5

Cited by 31 publications

(12 citation statements)

References 69 publications

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“…After burn injury, the rich milieu of denatured proteins and fats, loss of skin barrier function, and a variable degree of immunosuppression combine to magnify the risk of colonization and burn wound infection . Consequently, antimicrobial therapy was embraced in burn wound care . Systemic therapies for burn wound infection and prophylaxis have been limited by the metabolic perturbations that accompany burns and poor tissue penetration .…”

Section: Introductionmentioning

confidence: 99%

Ultrahigh dose gentamicin alters inflammation and angiogenesis in vivo and in vitro

Olekson

Rose

Carlsson

et al. 2017

Wound Repair Regeneration

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Skin quality outcome after skin grafting is adversely affected by wound bed inflammation. Neomycin, gentamicin, and other aminoglycoside antibiotics are known to modulate inflammation, and topical application affords the use of higher doses than are possible to use systemically. Previous data suggest that clinically relevant doses of neomycin, but not gentamicin, may impair angiogenesis, which is critical to the durable survival of skin grafts. The role of gentamicin at ultrahigh doses compared with clinically relevant neomycin doses in regulating inflammatory expression and angiogenesis has been examined. In a porcine skin replacement excisional wound model, continuous exposure to gentamicin increased anti-angiogenic and inflammatory expression at 7 days postgrafting. In in vitro studies, gentamicin also impaired angiogenesis in a human umbilical vein endothelial cell (HUVEC) tube formation model, increased the expression of the anti-angiogenic gene C-X-C motif chemokine 10 (CXCL10) in HUVECs and macrophages, and increased pro-inflammatory cytokine expression of macrophages in a dose-dependent manner. Neomycin exerted similar effects in vitro at clinically relevant doses on HUVEC tube formation and macrophage pro-inflammatory expression. CXCL10 was upregulated in macrophages, but did not exhibit a change in HUVECs with neomycin treatment. Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models. These findings suggest that topical administration of aminoglycosides have the potential to adversely influence early skin graft survival.

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Section: Introductionmentioning

confidence: 99%

Ultrahigh dose gentamicin alters inflammation and angiogenesis in vivo and in vitro

Olekson

Rose

Carlsson

et al. 2017

Wound Repair Regeneration

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“…[1][2][3] Clinically, the diagnosis of wound infection mostly relies on the clinical symptoms and examination of burn wounds. In the past 4 years, we have developed a porcine burn model 4 and assessed a total of 304 thermal burns sized 40 to 50 cm 2 (from 130 large white pigs).…”

mentioning

confidence: 99%

Burn Wound Infection in a Porcine Burn Model

Wang¹,

Liu²,

Kempf³

et al. 2009

Journal of Burn Care & Research

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“…Flamazine has antimicrobial properties against aerobic and anaerobic pathogens, and therefore limits bacterial colonisation. Its application is not painful in comparison to other antimicrobial crèmes/solutions, for example, mefanide acetate 16. MepilexBorder (Mölnlycke Health Care) and MepilexLite (Mölnlycke Health Care) incorporate a soft foam that absorbs low volumes of exudate 17 18.…”

Section: Discussionmentioning

confidence: 99%

Rare case of accidental fire and burns caused by e-cigarette batteries

et al. 2016

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E-cigarettes have become very popular among adult smokers, and many users carry e-cigarette devices and their components on their person. We present a case of a 35-year-old man who was admitted to our regional burns unit after his clothing was set-alight following the self-combustion of an e-cigarette lithium battery that was in his pocket. The patient had sustained a 1.5% mixed depth burn to the lateral aspect of his right thigh. Ward debridement under local anaesthetic was performed to remove clothing residue and reduce the risk of tattooing. Following conservative management with outpatient dressings, the burn wound healed by day 56.

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Treatment of infection in burns

Cited by 31 publications

References 69 publications

Ultrahigh dose gentamicin alters inflammation and angiogenesis in vivo and in vitro

Ultrahigh dose gentamicin alters inflammation and angiogenesis in vivo and in vitro

Burn Wound Infection in a Porcine Burn Model

Rare case of accidental fire and burns caused by e-cigarette batteries

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