“…Early investigations of Luteinizing Hormone Releasing Hormone (LHRH) demonstrated that administration of LHRH in a bolus pulsatile manner stimulated the release of gonadotropins, while chronic continuous administration induced an initial stimulation with a subsequent paradoxical inhibition of gonadotropin release (1,2). Taking advantage of this paradoxical phenomenon, clinical trials of long-acting LHRH analogues were undertaken and found to be successful in suppressing precocious puberty (3,4).…”