Treatment of hypogonadotropic hypogonadal male patients with the luteinizing hormone-releasing hormone (LH-RH) analog D-Ser-(TBU)6 EA10 LH-RH: transient disappearance of gonadotropin stimulation

Morel, Yves; Fournier, Monique; Mazenod, B; Tourniaire, J; Mornex, R

doi:10.1016/s0015-0282(16)46400-9

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Treatment Of Precocious Puberty With Continuous Subcutaneous1

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1983

1990

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Cited by 4 publications

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“…Early investigations of Luteinizing Hormone Releasing Hormone (LHRH) demonstrated that administration of LHRH in a bolus pulsatile manner stimulated the release of gonadotropins, while chronic continuous administration induced an initial stimulation with a subsequent paradoxical inhibition of gonadotropin release (1,2). Taking advantage of this paradoxical phenomenon, clinical trials of long-acting LHRH analogues were undertaken and found to be successful in suppressing precocious puberty (3,4).…”

Section: Treatment Of Precocious Puberty With Continuous Subcutaneousmentioning

confidence: 99%