Treatment of Hypertrophic Granulation Tissue with Topical Steroids

Shalom, A.; Wong, Lesley

doi:10.1097/00004630-200303002-00141

Cited by 7 publications

(25 citation statements)

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“…Such as chlorogenic acid, which ( Figure-2A, Figure-3), that indicates an improvement in the process of wound healing [44] . Because hypergranulation is problematic for wound healing and it is more likely to be associated with fibroplasia, and prolonged angiogenesis and inflammation [43,45,46] which might impair the process of wound healing through interfering epithelial cells migration across the surface of the wound bed [47] , and disturbing granulation tissue remodeling, which is critical for restoring damaged tissue architecture [44] . Post-injury inflammatory response control is known to be critical in wound healing [43,48] by reducing a chance of microbial infection, cellular debris degradation, releasing growth factors and cytokines.…”

Section: Treatments Timementioning

confidence: 99%

Effect of Hy ect of Hydroalcoholic Extr oalcoholic Extract of T act of Teucrium polium on the eucrium polium on the Process of Wound Healing in Diabetic Rats

Salih

Abdullah

Aziz

2020

passer

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Wound healing is physiological process, passing through three main overlapping phases, including inflammatory, proliferative, and remodeling phase to repair the damaged tissue. Some vital process in wound healing, including inflammatory cell infiltration, angiogenesis and collagen tissue formation, seems to be disrupted in diabetes, which is a metabolic disorder. The aims of this study were to investigate the effect of different concentrations of hydroalcoholic extract of Teucrium polium, which is a medicinal plant, on the process of wound healing in diabetic rats. Diabetes were induced in twenty adult Albino-rats using a single intraperitoneal injection of streptozocin. Five wounds were created on the back of each rat, and treated as control (untreated), vasaline-treated, and 5%, 10% or 15% Teucrium polium extract-treated. The results showed that Teucrium polium extract stimulated wound healing by enhancing the rate of wound retraction, angiogenesis, fibroblast proliferation, collagen deposition, and maturation. Although there was a reduction in the level of granulation tissue thickness deposition within the wound. The rate of the epithelial regeneration was improved, and the thickness of the regenerated epithelium was reduced. Overall, there was a promising impact of the extract on the process of wound healing through improving different phases of the process.

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Section: Treatments Timementioning

confidence: 99%

Effect of Hy ect of Hydroalcoholic Extr oalcoholic Extract of T act of Teucrium polium on the eucrium polium on the Process of Wound Healing in Diabetic Rats

Salih

Abdullah

Aziz

2020

passer

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“… 2 Furthermore, a prolonged stimulation of fibroplasia and angiogenesis may result in the formation of hypergranulation tissue that is problematic for wound healing. 5 , 9 …”

Section: Introductionmentioning

confidence: 99%

“…Treatment of hypergranulation tissue includes such methods as dressings that are less occlusive, 2 surgical excision, chemical cautery with silver nitrate, 11 , 12 hypertonic saline, 9 and laser ablation. 7 However, these treatments are often not considered uniformly successful.…”

Section: Introductionmentioning

confidence: 99%

“… 9 Topical corticosteroids have been reported to suppress the inflammatory response that contributes to the growth of this tissue. 1 , 9 , 13 , 14 Other mechanisms of action are the suppression of angiogenesis 1 , 9 and the reduction of edema related to stabilization of cell membranes. 9 However, much of the literature focuses on the treatment of keloid and hypertrophic scars because of the ability of steroids to reduce the excessive fibrous tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Hypergranulation tissue that develops in deep partial and full-thickness burns impedes epithelialization. 9 Topical steroid application for the treatment of hypergranulation tissue in burn wounds is standard care in our Burn Center in the Sheba Medical Center, Tel Hashomer, Israel. Here, we present the use of topical hydrocortisone in the treatment of hypergranulation tissue formation resulting from burn wounds.…”

Section: Introductionmentioning

confidence: 99%

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Treatment of hypergranulation tissue in burn wounds with topical steroid dressings: a case series

Jaeger¹,

Harats²,

Kornhaber³

et al. 2016

IMCRJ

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Hypergranulation tissue (or also known as overgranulation) may negatively influence burn wound healing time and contribute to recurrence of contractures in burn wounds and grafts. Subsequently, the treatment of hypergranulation tissue remains controversial and problematic. In this case series, we aimed to examine the feasibility and document the use of topical hydrocortisone in the treatment of hypergranulation tissue formation resulting from burn wounds. We report five cases where hypergranulation tissue developed following deep dermal/full-thickness burns. Initial burn wound treatment included necrotic tissue debridement, wound cleansing, and Flaminal®. All five cases underwent surgical debridement and split-skin grafting. Upon identification of hypergranulation tissue, hydrocortisone acetate 0.25% was applied topically as usual care for the treatment of hypergranulation tissue. All five patients had deep dermal/full-thickness burns with a total body surface area ranging from 22% to 61% and were aged from 3–41 years. All five cases developed hypergranulation tissue during their admission after debridement and split-thickness skin grafts. All patients showed an improvement in the treated areas with a complete regression of hypergranulation tissue and closure of the burn wounds. No clinically apparent local or systemic side effects of the treatment were observed. Topical hydrocortisone can be utilized as an effective, inexpensive, and noninvasive practical option in the treatment of hypergranulation tissue resulting from burn wounds.

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