Treatment of hypertensive urgencies and emergencies

Ram, C. Venkata S.; Silverstein, Russell L.

doi:10.1007/s11906-009-0053-2

Cited by 13 publications

(5 citation statements)

References 35 publications

(20 reference statements)

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“…In long term, the risk of end stage CRF is correlated with BMI, with individual risk of about one case per 1000 patient-years for a BMI ≥ 40 kg/m 2 [19], which shows a relative risk of 7 times more compared to normal weight subjects.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and the Risk Factors of Renal Insufficiency in the City of Saint Louis in Senegal

Lemrabott¹,

Cissé²,

Ka³

et al. 2015

OJNeph

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Background: The true scale of renal insufficiency (RI) in Sub-Saharan Africa remains unknown due to the lack of national registries. The aim of this study is to describe the epidemiological characteristics of renal insufficiency in urban areas in Saint Louis of Senegal. Materials and Methods: It is an observational, cross-sectional and descriptive study. The study was conducted during 27 days starting from 3 to 30 May 2010. All senegalese residents of Saint Louis (older than 15 years at the time of the study) in whom creatinine clearance was performed were included in the study. The sampling method used was a systematic random sampling, stratified cluster. The survey was designed by an expert comitee based on STEPS survey of the World Health Organization. RI was defined as a glomerular filtration rate (GFR) < 60 ml/min/1.73m 2 . Results: Among 1424 people initially selected a final selection of 1416 was made. The sex ratio was 0.45. The mean age was 43.4 ± 17.8 years. The overall prevalence of renal insufficiency according to MDRD (Modification of diet in renal disease) formula was 181 cases or 12.7%. The mean age of the people with renal insufficiency was 47.6 ± 17.4 years. Renal insufficiency was correlated to height blood pressure (p = 0.01) and Physical inactivity (p = 0.0001). The prevalence of renal insufficiency was higher in diabetics (71.4%) and obese people (66.6%) than in non-diabetics (64.9%) and non-obese people (56.5%), although the difference was not statistically significant. Dyslipidemia and smoking were not correlated to the risk of occurrence of IR. Conclusions: This study reports the increasing magnitude of RI and its risk factors in the city of Saint Louis in Senegal. It is imperative to establish à national prevention strategies to avoid the dizzying growth of this scourge.

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Section: Discussionmentioning

confidence: 99%

Prevalence and the Risk Factors of Renal Insufficiency in the City of Saint Louis in Senegal

Lemrabott¹,

Cissé²,

Ka³

et al. 2015

OJNeph

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“…This syndrome needs urgent intervention and treatment. 24 Intermittent evaluation of BP (systolic and diastolic BP) is necessary in order to document any changes due to GC therapy. Furthermore, any decrease or increase of BP medications (number or dosage) should be examined during the follow-up visits.…”

Section: Body Mass Index (Bmi)mentioning

confidence: 99%

Toxicity of glucocorticosteroids in autoimmune blistering diseases

Temel

Murrell

2019

Mucosa

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Glucocorticosteroids (GCs), have been the mainstay treatment for several dermatological diseases such as autoimmune bullous diseases (AIBDs). However, they come with a great cost of GCs-associated adverse events causing mortality and morbidity. Recently, a new measure to evaluate toxicity due to GCs' use has been demonstrated to be reliable. This review aimed to summarise toxicity attributed to GCs use and give more insight about this new toxicity index.

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“…Dihydropyridine Ca 2+ channel blockers are known to have potent coronary vasodilatory effects and have been widely used in patients with vasospastic angina [ 9 ]. Nicardipine, as a classic medication among dihydropyridine Ca 2+ channel blockers, has become a first-line treatment for acute hypertension because of its long half-life, rapid onset of action, ease of use, and low price [ 10 – 12 ]. Additionally, nicardipine’s antihypertensive effect can reflexively elevate heart rate while increasing cardiac output, with minimal impact on the heart.…”

Section: Introductionmentioning

confidence: 99%

Optimizing nicardipine dosage for effective control of pituitrin-induced hypertension in laparoscopic myomectomy undergoing total intravenous anesthesia

Wang,

Zhao,

Chen

et al. 2024

BMC Anesthesiol

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Background This study aimed to determine the median effective dose (ED50) and 95% effective dose (ED95) of nicardipine for treating pituitrin-induced hypertension during laparoscopic myomectomy, providing guidance for the management of intraoperative blood pressure in such patients. Methods Among the initial 40 participants assessed, 24 underwent elective laparoscopic myomectomy. A sequential up-and-down method was employed to ascertain the ED50 of nicardipine based on its antihypertensive efficacy. Nicardipine was initially administered at 6 µg/kg following the diagnosis of pituitrin-induced hypertension in the first patient. Dosing adjustments were made to achieve the desired antihypertensive effect, restoring systolic blood pressure and heart rate to within ± 20% of baseline within 120 s. The dosing increment or reduction was set at 0.5 µg/kg for effective or ineffective responses, respectively. The ED50 and ED95 of nicardipine were calculated using Probit regression by Maximum Likelihood Estimation (MLE) to establish dose-response curves and confidence intervals. Results 24 patients were included for analysis finally. The ED50 and ED95 of nicardipine for blood pressure control after pituitrin injection were determined. The study found that the ED50 of nicardipine for treating pituitrin-induced hypertension was 4.839 µg/kg (95% CI: 4.569–5.099 µg/kg), and the ED95 was estimated at 5.308 µg/kg (95% CI: 5.065–6.496 µg/kg). Nicardipine effectively mitigated the hypertensive response caused by pituitrin without inducing significant tachycardia or hypotension. Conclusions Nicardipine effectively controlled blood pressure after pituitrin injection during laparoscopic myomectomy, with ED50 and ED95 values established. This research highlights the potential utility of nicardipine in addressing hypertensive responses induced by pituitrin, particularly in clinical settings where pituitrin is routinely administered.

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Treatment of hypertensive urgencies and emergencies

Cited by 13 publications

References 35 publications

Prevalence and the Risk Factors of Renal Insufficiency in the City of Saint Louis in Senegal

Prevalence and the Risk Factors of Renal Insufficiency in the City of Saint Louis in Senegal

Toxicity of glucocorticosteroids in autoimmune blistering diseases

Optimizing nicardipine dosage for effective control of pituitrin-induced hypertension in laparoscopic myomectomy undergoing total intravenous anesthesia

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