Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease

Rosendorff, Clive; Black, Henry R.; Cannon, Christopher P.; Gersh, Bernard J.; Gore, Joel M.; Izzo, Joseph L.; Kaplan, Norman M.; O’Connor, Christopher M.; O’Gara, Patrick T.; Oparil, Suzanne

doi:10.1161/circulationaha.107.183885

Cited by 688 publications

(252 citation statements)

References 209 publications

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“…More recently, the AHA, ACC, and ASH published a new guideline, endorsing a goal of <140/90 mm Hg for those with hypertension and CVD with an optional target of <130/80 mm Hg for those with CVD and previous MI, stroke/TIA, carotid artery disease, peripheral arterial disease, or abdominal aortic aneurysm 43. ESH/ESC recommends a goal of <140/90 mm Hg for adults with CVD, while other societies do not have specific treatment goals for this population.…”

Section: Jnc 8 Recommendations 2 Tomentioning

confidence: 99%

US Hypertension Management Guidelines: A Review of the Recent Past and Recommendations for the Future

Kovell

Ahmed

Misra

et al. 2015

JAHA

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Section: Jnc 8 Recommendations 2 Tomentioning

confidence: 99%

US Hypertension Management Guidelines: A Review of the Recent Past and Recommendations for the Future

Kovell

Ahmed

Misra

et al. 2015

JAHA

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“…Nowadays medical practice has at its disposal unimaginable great number of antihypertensive and diuretic means, allowing refinement at combining of single representatives. In this way is reached not only maximum antihypertensive effect but also favourable outcome of all complications, connected with the disease [5,7,9].…”

mentioning

confidence: 79%

Acute poisoning with antihypertensive and antiarrhythmic medicines - clinicoepidemiological study

Stoyanova¹,

Saeva²

2017

Medical news of the North Caucasus

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The characteristics of acute poisoning with antihypertensive and antiarrhythmic medicines were investigated in the retrospective epidemiological study. All cases of antihypertensive and antiarrhythmic medicines (AAM) poisoning were analyzed for 3 years period. Demographic data, previous illness were obtained retrospectively. The cases of poisonings were evaluated with respect to clinical course, therapy and outcome. 896 patients with acute exogenous intoxications were treated. 136 cases (15.2 %) of them were poisoning with AAM -beta-blockers, calcium channel blockers, angiotensin converting enzyme inhibitors, etc. 95 (69.9 %) were female and 41 (30.1 %) male, between the ages of 18 and 98. 61 individuals (44.9 %) were poisoned by only one drug. In 75 (55.1 %) remaining cases, intoxications were mixed, including other different medications or psychoactive substances. 112 cases (86.8 %) were intentional -a result of a suicide attempt. The severity of poisonings varied from moderate to extremely severe. In 17 patients poisoning occurs with the signs of exotoxic shock, 3 of them -with fatal outcome. In the examined group three patients died of cardiogenic shock and secondary acute respiratory failure resistant to therapy. In conclusion, patients with acute poisoning from AAM were a large proportion of all patients, received acute poisoning and represent a serious challenge for the physician -toxicologist.

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“…[1] Although these control rates may be true for the recommended BP goals of <140/90 mmHg for uncomplicated hypertension, the control rates for the more aggressive goal of <130/80 mmHg for persons with diabetes mellitus, chronic renal disease, or coronary heart disease (CHD) are lower. [2][3][4][5] Most studies show that in order to reach these goals, the majority of patients will require two or more antihypertensive drugs. [6][7][8][9][10] Calcium-channel blockers (CCBs) and angiotensin-converting enzyme (ACE) inhibitors are still recommended for first-line therapy for hypertension, [2,3] but given alone, do not produce BP reductions to currently recommended BP goals, and in most patients with stage 2 hypertension, a combination of two drugs from different classes is recommended.…”

Section: Introductionmentioning

confidence: 99%

Blood Pressure Effects of High-Dose Amlodipine-Benazepril Combination in Black and White Hypertensive Patients Not Controlled on Monotherapy

Chrysant

2012

Drugs R D

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Background: Black hypertensive patients are more resistant to angiotensinconverting enzyme (ACE) inhibitor monotherapy than White patients. This resistance can be overcome with the combination of ACE inhibitors with diuretics or calcium-channel blockers (CCBs). Objectives: The objective of this clinical investigation was to evaluate the antihypertensive effectiveness of monotherapy with the ACE inhibitor benazepril or the CCB amlodipine and their combination in Black and White hypertensive patients in two separate studies. Methods: This was a post hoc analysis of data from two separate studies, pooled because of their similarities, to increase the sample size. Outpatient Black and White hypertensive patients were selected for these studies. In study H2303, 201 patients of both sexes and races, whose mean seated diastolic blood pressure (MSDBP) was ‡95 mmHg after 4 weeks of single-blind treatment with benazepril 40 mg/day, were randomized into two groups.

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Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease

Cited by 688 publications

References 209 publications

US Hypertension Management Guidelines: A Review of the Recent Past and Recommendations for the Future

US Hypertension Management Guidelines: A Review of the Recent Past and Recommendations for the Future

Acute poisoning with antihypertensive and antiarrhythmic medicines - clinicoepidemiological study

Blood Pressure Effects of High-Dose Amlodipine-Benazepril Combination in Black and White Hypertensive Patients Not Controlled on Monotherapy

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