Treatment of Hodgkin Lymphoma – New and Developing Therapies and Their Potential Role in Standard of Care

Vassilakopoulos, Theodoros P.; Böll, Boris

doi:10.17925/eoh.2019.15.1.53

Cited by 1 publication

(1 citation statement)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…44 Thus, BrECADD was selected to be compared with the GHSG standard of care of six cycles of BEACOPP-escalated in the HD21 trial for advanced cHL. 45…”

Section: Summary Of Current First-line Therapy In Chlmentioning

confidence: 99%

Optimizing outcomes in relapsed/refractory Hodgkin lymphoma: a review of current and forthcoming therapeutic strategies

Vassilakopoulos

Asimakopoulos

Konstantopoulos

et al. 2020

Therapeutic Advances in Hematology

View full text Add to dashboard Cite

The outcome of patients with relapsed/refractory classical Hodgkin lymphoma (rr-cHL) has improved considerably in recent years owing to the approval of highly active novel agents such as brentuximab vedotin and Programmed Death-1 (PD-1) inhibitors. Although no randomized trials have been conducted to provide formal proof, it is almost undisputable that the survival of these patients has been prolonged. As autologous stem-cell transplantation (SCT) remains the standard of care for second-line therapy of most patients with rr-cHL, optimization of second-line regimens with the use of brentuximab vedotin, or, in the future, checkpoint inhibitors, is promising to increase both the eligibility rate for transplant and the final outcome. The need for subsequent therapy, and especially allogeneic SCT, can be reduced with brentuximab vedotin consolidation for 1 year, while pembrolizumab is also being tested in this setting. Several other drug categories appear to be active in rr-cHL, but their development has been delayed by the appearance of brentuximab vedotin, nivolumab and pembrolizumab, which have dominated the field of rr-cHL treatment in the last 5 years. Combinations of active drugs in chemo-free approaches may further increase efficacy and hopefully reduce toxicity in rr-cHL, but are still under development.

show abstract

“…44 Thus, BrECADD was selected to be compared with the GHSG standard of care of six cycles of BEACOPP-escalated in the HD21 trial for advanced cHL. 45…”

Section: Summary Of Current First-line Therapy In Chlmentioning

confidence: 99%