Treatment of High-Risk Gestational Trophoblastic Tumors

Wright, Jason D.; Mutch, David G.

doi:10.1097/00003081-200309000-00010

Cited by 16 publications

(21 citation statements)

References 55 publications

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“…4,12 However, the indications for hysterectomy in high-risk patients are more controversial. 9,13Y15 The purpose of this retrospective study was to evaluate the role of hysterectomy and clarify the indications for this procedure in high-risk patients with malignant GTN. We therefore analyzed clinical records of patients treated for malignant GTN during a 20-year period at a university medical hospital in China.…”

mentioning

confidence: 99%

Role of Adjuvant Hysterectomy in Management of High-Risk Gestational Trophoblastic Neoplasia

Fang

Wang

Han³

et al. 2012

Int J Gynecol Cancer

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Our study suggests that timely adjuvant hysterectomy is likely to benefit cautiously selected patients with high-risk gestational trophoblastic neoplasia. Although preoperative metastases limited to pelvic organs or lungs should not be considered an absolute contraindication, adjuvant hysterectomy should generally not be performed in the presence of distant metastases beyond the pelvic organs and lungs.

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mentioning

confidence: 99%

Role of Adjuvant Hysterectomy in Management of High-Risk Gestational Trophoblastic Neoplasia

Fang

Wang

Han³

et al. 2012

Int J Gynecol Cancer

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“…The main non-hematologic toxic effect caused by etoposide (other than those mentioned previously) is the possibility of secondary malignancy [23].…”

Section: Discussionmentioning

confidence: 88%

Comparison of methotrexate, actinomycin D, and etoposide for treating low‐risk gestational trophoblastic neoplasia

Baptista

Belfort²

2012

Intl J Gynecology & Obste

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“…In women with a high-risk GTD, multidrug chemotherapy has been shown to be superior to single-drug chemotherapy [8]. …”

Section: Discussionmentioning

confidence: 99%

Pancreatic and Hepatic Metastasis of an Undiagnosed Choriocarcinoma: An Exceptional Cause of Haemoperitoneum in Young Women – Report of a Rare Case

Fatema¹,

Arora²,

Abri³

et al. 2016

Case Rep Oncol

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Haemoperitoneum in women of reproductive age usually suggests either ruptured ectopic pregnancy or ruptured ovarian cysts. Metastatic choriocarcinoma is considered the least common cause of haemoperitoneum in women of childbearing age. We report a rare case of pancreatic and hepatic metastasis of choriocarcinoma in a young, 30-year-old female who had delivered 10 months prior at term gestation with no previous history of gestational trophoblastic disease or molar pregnancy. She had a short history of fever and pain in the right hypochondrium, with findings of hypovolaemic shock due to intraperitoneal haemorrhage. Unfortunately, the patient expired with massive uncontrolled bleeding from liver metastasis despite 2 emergency laparotomies within 12 h. This case report is an apt reminder to clinicians to include metastatic choriocarcinoma on the list of differential diagnoses for haemoperitoneum with a positive pregnancy test in women of reproductive age to diagnose early and to avoid life-threatening consequences.

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Treatment of High-Risk Gestational Trophoblastic Tumors

Cited by 16 publications

References 55 publications

Role of Adjuvant Hysterectomy in Management of High-Risk Gestational Trophoblastic Neoplasia

Role of Adjuvant Hysterectomy in Management of High-Risk Gestational Trophoblastic Neoplasia

Comparison of methotrexate, actinomycin D, and etoposide for treating low‐risk gestational trophoblastic neoplasia

Pancreatic and Hepatic Metastasis of an Undiagnosed Choriocarcinoma: An Exceptional Cause of Haemoperitoneum in Young Women – Report of a Rare Case

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