Treatment of herpesvirus associated primary effusion lymphoma with intracavity cidofovir

Primary Effusion Lymphoma

“…These include the addition of antiviral therapy as well as inhibition of specific cellular targets. Two recent reports have described treating four elderly patients with intrapleural injections of the antiviral drug cidofovir with durations of remissions lasting several months [62,63]. The efficacy of antiviral treatment can potentially be improved if PEL cells can be induced to enter the lytic phase of viral replication, as the majority of antiviral drugs are most effective in the lytic phase.…”

Human Herpesvirus 8–Related Primary Effusion Lymphoma After Liver Transplantation

“…Intrapleural cidofovir 3 mg/kg was trialed based on previously published reports using this approach in nontransplant-related primary effusion lymphoma (PEL) patients (6,7). While the initial treatment plan was for weekly cidofovir installations, he developed acute renal failure following the first dose.…”

Antineoplastic effects of liposomal short interfering RNA treatment targeting BLIMP1/PRDM1 in primary effusion lymphoma

“…For in vitro experiments, PEL cell lines (BCBL-1, HBL-6 and CRO-AP/3) were cultured in fetal calf serum-supplemented RPMI 1640 medium, as described elsewhere, 13,14 and were treated with siRNA against BLIMP1/PRDM1 (siRNA sequences in the Online Supplementary Information) complexed with liposomes to form anti-BLIMP1 siRNA lipoplexes (formulated and characterized as previously described). [10][11][12] The same liposomes, either loaded with scrambled oligonucleotides (i.e.…”