Treatment of hepatocellular carcinoma with in situ generated plasma‐activated air‐driven water mist

Abstract

Since the development of cold atmospheric plasma (CAP), substantial and significant usage of CAP applications was introduced in medicine. Here, we developed two combined sources of plasma to produce in situ plasma‐activated air‐driven water mist (PAAWM). The first is generated using air as a feed gas, while the second is plasma‐activated water generated by the ignition of plasma within the air‐driven water mist. Both contribute to the plasma jet generation of PAAWM. The antitumor efficacy of PAAWM was evaluated against two hepatocellular carcinoma cell lines (SNU‐449 and SNU‐475). The generated PAAWM was efficient in the treatment of both chemosensitive and chemoresistant hepatocellular carcinoma cells. These results may support using PAAWM alone or in combination with other treatment modalities.

Recent Developments in the Use of Plasma in Medical Applications

“…Saadaway et al described a similar approach to deliver therapeutic doses of PAW mist. They termed their technique as plasma-activated air-driven water mist (PAAWM) and showed that the resultant mist was effective against multiple cancer cell lines in an in vitro study [133].…”

Special issue: Plasma Medicine ‐ part I

“…Another popular application of cold plasmas and plasma‐treated media is in the field of oncology as an anticancer treatment strategy, as shown in the paper by Saadawy et al [ 8 ] This paper presents a novel approach for the treatment of hepatocellular carcinoma using plasma‐treated air‐driven water mist. The findings highlight plasma‐generated reactive species to induce selective cancer cell death, providing a promising avenue for noninvasive cancer therapies.…”