1977
DOI: 10.1136/bmj.2.6094.1047
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Treatment of hepatic hydatid disease with mebedazole: preliminary results in four cases.

Abstract: indicate a need for further rationalising the provision and distribution of special care baby units. The case for this is further strengthened by our other findings. Even in the three well-endowed regions in this study it has not proved possible to staff and equip all officially recognised units to the standard recommended by the expert group. Moreover, since the group's report was published, increasing technological requirements together with inflation have made it a continuing struggle to maintain the standa… Show more

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Cited by 189 publications
(65 citation statements)
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“…Surgery was first reported in the treatment of human CE in 1821, 25 use of benzimidazole was first reported in 1977 26 and successful percutaneous drainage was first reported in 1985. 27 Despite all three modalities of treatment being concurrently available for almost 30 years, optimal treatment for CE is yet to be fully determined.…”
Section: Discussionmentioning
confidence: 99%
“…Surgery was first reported in the treatment of human CE in 1821, 25 use of benzimidazole was first reported in 1977 26 and successful percutaneous drainage was first reported in 1985. 27 Despite all three modalities of treatment being concurrently available for almost 30 years, optimal treatment for CE is yet to be fully determined.…”
Section: Discussionmentioning
confidence: 99%
“…6 The efficacy of high doses of mebendazole or albendazole is still unproved. [9][10][11] A high dose has sometimes been associated with severe neutropenia, suppression of red blood cells and platelets. 10 Tumor formation has been reported in experimental animals treated with albendazole.…”
Section: Discussionmentioning
confidence: 99%
“…2 The effective dosage is very high, around 100 Gy. The use of mebendazole 21 before surgery to attenuate the scoleces has been suggested, but this is still in its early stages. Though some authors have advised its use as a curative measure for selected cases, 21,22 mebendazole is not well absorbed and probably acts by blocking the glucose uptake by nematodes in the colon.…”
Section: Therapymentioning
confidence: 99%
“…The use of mebendazole 21 before surgery to attenuate the scoleces has been suggested, but this is still in its early stages. Though some authors have advised its use as a curative measure for selected cases, 21,22 mebendazole is not well absorbed and probably acts by blocking the glucose uptake by nematodes in the colon. 10 Animal data in pregnant rats have demonstrated embryotoxic and teratogenic effects following a single oral dose of 10 mg/kg of body weight.…”
Section: Therapymentioning
confidence: 99%