Treatment of hepatic alveolar echinococcosis infringing the inferior vena cava

Du, Qiancheng; Zhou, Ying; Fan, Haining

doi:10.1590/0037-8682-0342-2018

Cited by 3 publications

(3 citation statements)

References 2 publications

(2 reference statements)

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“…Radical hepatectomy is the first choice for the treatment of HAE and liver cancer 5,6 . For patients with liver cancer, if they exist extrahepatic metastasis, then they have lost the opportunity of radical surgery 7 .…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The diagnostic nomogram of platelet-based score models for hepatic alveolar echinococcosis and atypical liver cancer

Wang

Guan

et al. 2019

Sci Rep

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Hepatic alveolar echinococcosis (HAE) and liver cancer had similarities in imaging results, clinical characteristics, and so on. And it is difficult for clinicians to distinguish them before operation. The aim of our study was to build a differential diagnosis nomogram based on platelet (PLT) score model and use internal validation to check the model. The predicting model was constructed by the retrospective database that included in 153 patients with HAE (66 cases) or liver cancer (87 cases), and all cases was confirmed by clinicopathology and collected from November 2011 to December 2018. Lasso regression analysis model was used to construct data dimensionality reduction, elements selection, and building prediction model based on the 9 PLT-based scores. A multi-factor regression analysis was performed to construct a simplified prediction model, and we added the selected PLT-based scores and relevant clinicopathologic features into the nomogram. Identification capability, calibration, and clinical serviceability of the simplified model were evaluated by the Harrell’s concordance index (C-index), calibration plot, receiver operating characteristic curve (ROC), and decision curve. An internal validation was also evaluated by the bootstrap resampling. The simplified model, including in 4 selected factors, was significantly associated with differential diagnosis of HAE and liver cancer. Predictors of the simplified diagnosis nomogram consisted of the API index, the FIB-4 index, fibro-quotent (FibroQ), and fibrosis index constructed by King’s College Hospital (King’s score). The model presented a perfect identification capability, with a high C-index of 0.929 (0.919 through internal validation), and good calibration. The area under the curve (AUC) values of this simplified prediction nomogram was 0.929, and the result of ROC indicated that this nomogram had a good predictive value. Decision curve analysis showed that our differential diagnosis nomogram had clinically identification capability. In conclusion, the differential diagnosis nomogram could be feasibly performed to verify the preoperative individualized diagnosis of HAE and liver cancer.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The diagnostic nomogram of platelet-based score models for hepatic alveolar echinococcosis and atypical liver cancer

Wang

Guan

et al. 2019

Sci Rep

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“…IL-1β secreted by Kupffer cells is an important factor causing liver damage[ 64 ]. In a previous study[ 36 ], we observed typical chronic granulomatous changes around the lesion, accompanied by lymphocyte infiltration, hepatocyte degeneration and necrosis, and Kupffer cell proliferation and differentiation in tissues from patients with HAE. In this study, we used CD68 to identify Kupffer cells, and confirmed that they play an important role in the marginal zone.…”

Section: Discussionmentioning

confidence: 79%

“…The occurrence and development of parasitic diseases is often accompanied by inflammation[ 34 , 35 ]. In a previous study, we determined that HAE has a clear marginal zone[ 36 ]. However, the role and clinical significance of the NLRP3 inflammasome in HAE remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis

Chen¹,

Zhang²,

Wang³

et al. 2023

World J Gastroenterol

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BACKGROUND The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a significant component of the innate immune system that plays a vital role in the development of various parasitic diseases. However, its role in hepatic alveolar echinococcosis (HAE) remains unclear. AIM To investigate the NLRP3 inflammasome and its mechanism of activation in HAE. METHODS We assessed the expression of NLRP3, caspase-1, interleukin (IL)-1β, and IL-18 in the marginal zone and corresponding normal liver of 60 patients with HAE. A rat model of HAE was employed to investigate the role of the NLRP3 inflammasome in the marginal zone of HAE. Transwell experiments were conducted to investigate the effect of Echinococcus multilocularis ( E. multilocularis ) in stimulating Kupffer cells and hepatocytes. Furthermore, immunohistochemistry, Western blotting, and enzyme-linked immunosorbent assay were used to evaluate NLRP3, caspase-1, IL-1β, and IL-18 expression; flow cytometry was used to detect apoptosis and reactive oxygen species (ROS). RESULTS NLRP3 inflammasome activation was significantly associated with ROS. Inhibition of ROS production decreased NLRP3-caspase-1-IL-1β pathway activation and mitigated hepatocyte damage and inflammation. CONCLUSION E. multilocularis induces hepatocyte damage and inflammation by activating the ROS-mediated NLRP3-caspase-1-IL-1β pathway in Kupffer cells, indicating that ROS may serve as a potential target for the treatment of HAE.

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Retraction Note: The diagnostic nomogram of platelet-based score models for hepatic alveolar echinococcosis and atypical liver cancer

Wang

Guan

et al. 2020

Sci Rep

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Treatment of hepatic alveolar echinococcosis infringing the inferior vena cava

Cited by 3 publications

References 2 publications

RETRACTED ARTICLE: The diagnostic nomogram of platelet-based score models for hepatic alveolar echinococcosis and atypical liver cancer

RETRACTED ARTICLE: The diagnostic nomogram of platelet-based score models for hepatic alveolar echinococcosis and atypical liver cancer

Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis

Retraction Note: The diagnostic nomogram of platelet-based score models for hepatic alveolar echinococcosis and atypical liver cancer

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