Treatment of heart block due to sarcoid heart disease

Lash, Ray E.; Coker, J E; Wong, Bert Y.S.

doi:10.1016/s0022-0736(79)80068-0

Cited by 12 publications

(3 citation statements)

References 20 publications

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“…Since the prognosis of myocardial sarcoidosis is claimed to be poor (17), early probable diagnosis is important. Corticosteroid therapy in the early stages of the disease can be effective and earlier studies (16, 18,19) have reported normalization of atrioventricular and repolarization disturbances after such therapy. Thus, patients with sarcoidosis and persisting abnormal ST-T changes in their exercise ECG after #?-adrenergic blockade should be carefully followed up and corticosteroid therapy should be considered.…”

Section: Discussionmentioning

confidence: 97%

Exercise Test in Patients with Sarcoidosis

Thunell

Bjerle

Karp

et al. 1988

Journal of Internal Medicine

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The study population comprises 28 patients with sarcoidosis who all had repolarization disturbances in their exercise ECGs. None of the patients had hypertension or known cardiovascular disease, and all but two were non‐smokers. The mean age was 45 years. Exercise test with β‐adrenergic blockade was performed within one month of the first examination. Persisting abnormal ST‐T changes in exercise ECGs after β‐blockade were seen in 12 (43%) patients. No significant relationship was found between persisting ST‐T changes and age, sex, chest X‐ray stage, lung function or working capacity. In an earlier study, we found ST‐T abnormalities in exercise ECG in 56 of 127 individuals (44%) in a consecutive 5‐year study of patients with newly detected sarcoidosis. From this and the present report we postulate that, in our region, as much as 20% of the patients with newly detected sarcoidosis might have organic myocardial disease, possibly of sarcoid origin, as shown by repolarization disturbances in exercise ECG. If ECG abnormalities in the ST‐T region are present in patients with sarcoidosis, exercise ECG with β‐blockade is a simple way of establishing suspicion of organic myocardial lesions. If exercise ECG abnormalities in the ST‐T region persist after β‐blockade, careful clinical follow‐up is recommended, and, in some patients early steroid therapy should be considered.

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Section: Discussionmentioning

confidence: 97%

Exercise Test in Patients with Sarcoidosis

Thunell

Bjerle

Karp

et al. 1988

Journal of Internal Medicine

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“…47 Although most of the supporting data are anecdotal, steroids have been shown to improve ventricular contractility, 48 arrhythmias, 49 and conduction abnormalities. 50 PET studies have shown cardiac lesions resolving after steroids were started. 31,45,46 The optimal dosage remains unknown.…”

Section: Corticosteroidsmentioning

confidence: 99%

A middle-aged man with progressive fatigue

McDivit

Askari

2009

CCJM

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“…Resolution of electrocardiographic abnormalities [65], arrhythmias [66,67], conduction abnormalities [54,68,69] and disappearance of Q waves [70] have been reported with steroid therapy. Myocardial perfusion defects on thallium and technetium scans have improved or disappeared after a course of steroids [50,71].…”

Section: Corticosteroidsmentioning

confidence: 99%