Treatment of head lice with dimeticone 4% lotion: comparison of two formulations in a randomised controlled trial in rural Turkey

Kurt, Özgür; Balcıoğlu, İbrahim; Burgess, Ian F.; Limoncu, M. Emin; Girginkardeşler, Nogay; Tabak, Tuba; Muslu, Hasan; Ermiş, Özge; Sahin, M Turhan; Bilaç, Cemal; Kavur, Hakan; Özbel, Yusuf

doi:10.1186/1471-2458-9-441

Cited by 37 publications

(35 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the products with physical action and insufficient ovidicidal activity, Pouxit® (also known under the name of Etopril®, Silicom®, XTLuis®, Piky®, Headring®, Neositrin®, Hedrin®) was tested in clinical trials (Burgess et al 2005Kurt et al 2009). …”

Section: Discussion Per Productmentioning

confidence: 99%

Ex vivo effectiveness of French over-the-counter products against head lice (Pediculus humanus capitis De Geer, 1778)

et al. 2015

View full text Add to dashboard Cite

Head lice infestation is still a public health problem worldwide, with an intracountry and intercountry prevalence variation of 0.7 to 59%. There is a large variety of over-the-counter anti-louse products, but their efficacy is not always well assessed. Our objective was to test the pediculicidal and ovicidal efficacy of 21 over-the-counter head louse products, available in France during the period of 2008 to 2012. We tested children living in Tours City in central France and visiting preschools, primary schools, kindergarten, camps, and child care facilities, as well as children in their family houses, and were examined for the presence of lice. The products were collected from randomly selected pharmacies by covert investigators and then tested in the laboratory on an ex vivo sample of head lice and their eggs, collected from the hair of infested children. Living lice and unharmed eggs were collected from the scalps of 3-12 years old. The laboratory conditions for ex vivo testing mimicked the manufacturers' instructions for exposure time and application method. In 21 runs, 3919 living lice and 4321 undamaged living eggs were collected from the scalp of over 400 children. The 21 products were classified in three groups: 6 products in a group of potentially 100% pediculicidal activity and potentially 100% ovicidal activity, 8 products in a group of potentially 100% pediculicidal activity but insufficient ovicidal activity (including 2 products with claims of single application treatment), and 7 products in a group of insufficient pediculicidal activity and ovicidal activity. The pharmaceutical market for head lice products in France is swamped with poorly tested and ineffective products. Rigorous efficacy testing preregistration and periodic screening and testing of effectiveness in the post-registration period should be endorsed by the health authorities.

show abstract

Section: Discussion Per Productmentioning

confidence: 99%

Ex vivo effectiveness of French over-the-counter products against head lice (Pediculus humanus capitis De Geer, 1778)

et al. 2015

View full text Add to dashboard Cite

show abstract

“…[92] Dimeticone 4% lotion Physical Made from high molecular weight dimeticone in cyclomethicone base, 4 randomized controlled trials have shown its high efficacy. [93][94][95][96] 15-minute application also effective. [97] Lice unlikely to develop resistance due to its physical action.…”

Section: Ivermectin (Vs Malathion)mentioning

confidence: 91%

“…[86] Treatment Increasing resistance and adverse effects have raised concerns about head lice treatments, [87] encouraging search for new treatments [ Table 4]. [88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103] No available pediculicide is 100% ovicidal, and resistance to lindane, pyrethrins, permethrin, and malathion has been reported. [100] Nits persist after the treatment and may be mistaken for active infestation [ Figure 5].…”

Section: Pediculosismentioning

confidence: 99%

See 1 more Smart Citation

Insect bite reactions

Singh¹,

Mann²

2013

Indian J Dermatol Venereol Leprol

View full text Add to dashboard Cite

Insects are a class of living creatures within the arthropods. Insect bite reactions are commonly seen in clinical practice. The present review touches upon the medically important insects and their places in the classification, the sparse literature on the epidemiology of insect bites in India, and different variables influencing the susceptibility of an individual to insect bites. Clinical features of mosquito bites, hypersensitivity to mosquito bites Epstein-Barr virus NK (HMB-EBV-NK) disease, eruptive pseudoangiomatosis, Skeeter syndrome, papular pruritic eruption of HIV/AIDS, and clinical features produced by bed bugs, Mexican chicken bugs, assassin bugs, kissing bugs, fleas, black flies, Blandford flies, louse flies, tsetse flies, midges, and thrips are discussed. Brief account is presented of the immunogenic components of mosquito and bed bug saliva. Papular urticaria is discussed including its epidemiology, the 5 stages of skin reaction, the SCRATCH principle as an aid in diagnosis, and the recent evidence supporting participation of types I, III, and IV hypersensitivity reactions in its causation is summarized. Recent developments in the treatment of pediculosis capitis including spinosad 0.9% suspension, benzyl alcohol 5% lotion, dimethicone 4% lotion, isopropyl myristate 50% rinse, and other suffocants are discussed within the context of evidence derived from randomized controlled trials and key findings of a recent systematic review. We also touch upon a non-chemical treatment of head lice and the ineffectiveness of egg-loosening products. Knockdown resistance (kdr) as the genetic mechanism making the lice nerves insensitive to permethrin is discussed along with the surprising contrary clinical evidence from Europe about efficacy of permethrin in children with head lice carrying kdr-like gene. The review also presents a brief account of insects as vectors of diseases and ends with discussion of prevention of insect bites and some serious adverse effects of mosquito coil smoke.

show abstract

“…In a randomized controlled clinical trial conducted in this country with the former pediculicide, a high cure rate was observed 12 .…”

Section: öZetmentioning

confidence: 99%

The near future of head louse control

Mumcuoglu¹

2015

Cumhuriyet Med J

View full text Add to dashboard Cite

SUMMARYInfestation with head lice is a worldwide public health concern. In high income countries pediculosis capitis is a problem mainly in school-aged children. In the last two decades and mainly as a result of resistance to pediculicides with a neurotoxic mode of action and due to the toxicological concerns, a new trend to products acting by physical means such as dimethicone, has been observed. It was shown that these substances are capable of entering the tracheal system and asphyxiating the lice and their eggs. Due to this quality it could be expected that lice, if at all, could not easily develop resistance. Dimethicone is a cosmetically acceptable product, physiologically inert and non-toxic and therefore it is expected to become the treatment-of-choice for lice in the near future.

show abstract

Treatment of head lice with dimeticone 4% lotion: comparison of two formulations in a randomised controlled trial in rural Turkey

Cited by 37 publications

References 10 publications

Ex vivo effectiveness of French over-the-counter products against head lice (Pediculus humanus capitis De Geer, 1778)

Ex vivo effectiveness of French over-the-counter products against head lice (Pediculus humanus capitis De Geer, 1778)

Insect bite reactions

The near future of head louse control

Contact Info

Product

Resources

About