Treatment of Granuloma Inguinale with Erythromycin1

Robinson, Harry M.; Cohen, Morris M.

doi:10.1038/jid.1953.50

Cited by 23 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… Co-trimoxazole 160/800 mg bd orally: 1B 19 Doxycycline 100 mg bd orally: 1C (evidence is not available from clinical trials, but older tetracyclines have been observed to be effective) 20 Erythromycin 500 mg four times daily orally. Recommended in pregnancy: 1C 21 Gentamicin 1 mg/kg every 8 h parenterally can also be used as an adjunct if lesions are slow to respond 1C 3 …”

Section: Managementmentioning

confidence: 99%

2018 UK national guideline for the management of donovanosis

O’Farrell

Hoosen

Kingston³

2018

Int J STD AIDS

View full text Add to dashboard Cite

The objective of this guideline is to provide guidance for the diagnosis and management of donovanosis, a now rare sexually transmitted infection. This guidance is primarily for professionals working in UK Sexual Health services (although others may find it useful) and refers to the management of individuals presenting with possible symptoms of donovanosis who are over the age of 16. An updated literature review since the last Clinical Effectiveness Group (CEG) guideline produced for this condition in 2011 has shown few new developments. Most reports in the literature relate to cases of unusual presentations of the condition.

show abstract

Section: Managementmentioning

confidence: 99%

2018 UK national guideline for the management of donovanosis

O’Farrell

Hoosen

Kingston³

2018

Int J STD AIDS

View full text Add to dashboard Cite

show abstract

“…Recommended in pregnancy (Grade C, Level IV). 16 However, azithromycin is now probably the drug of choice in pregnant women…”

Section: Managementmentioning

confidence: 99%

European guideline for the management of donovanosis, 2010

O’Farrell

Moi

2010

Int J STD AIDS

View full text Add to dashboard Cite

Donovanosis is a rare sexually transmitted infection now mainly seen in sporadic cases in Papua New Guinea, South Africa, India, Brazil and Australia. The causative organism is Calymmatobacterium granulomatis though a proposal has been put forward that the organism be reclassified as Klebsiella granulomatis comb. nov. The incubation period is approximately 50 days with genital papules developing into ulcers that increase in size. Four types of lesions are described – ulcerogranulomatous, hypertrophic, necrotic and sclerotic. The diagnosis is usually confirmed by microscopic identification of characteristic Donovan bodies on stained tissue smears. More recently, polymerase chain reaction (PCR) methods have been developed. The recommended treatment is azithromycin 1 g weekly until complete healing is achieved.

show abstract

“…D'autres antibiotiques ont montré leur efficacité sur de petites séries comme l'érythromycine [7], l'ampicilline [8,9) et la lincomycine [8]. Toutefois, en seconde intention, vient certainement le cotrimoxazole [10] (association trimethoprime et sulfaméthoxazole) avec lequel Lal et Garg [11] ne signalent aucun échec sur une série de 116 patients.…”

Section: Observationunclassified