Treatment of Grade I and II types of xanthelasma palpebrarum with intralesional heparin sodium

Treatment of xanthelasma palpebrarum with intralesional heparin sodium: a pilot study

“…The technique has been dropped for centuries, until its recent reintroduction for treating XP. 4 However, reports of its use are limited to early XP in Asian populations and are almost absent in the English literature.…”

“…The study was conducted between January 2020 and June 2021. As in the study of Ren et al, 4 and to get comparable results, XP lesions were classified into four grades with Grade I being the mildest with lesions involving only the upper eyelids.…”

“…PTCL-NOS is thus a diagnosis of exclusion, integrating in the appropriate clinical context, the presence of histopathological features distinctive of lymphoma with an aberrant T-cell immunophenotype and a clonal T-cell receptor gene rearrangement. 4 A 39-year-old man presented with a nodular lesion in the left periorbital area evolving for 1 month. A computerized tomography (CT) scan of the left orbit was consistent with cellulitis.…”

Clinical and dermoscopic assessment of ablative carbon dioxide laser versus intradermal heparin sodium in xanthelasma

“…Therefore, Cornbleet 9 suggested it as a promising treatment option for xanthomas since 1955. However, this approach was neglected for several decades, and in the last decade, two former studies assessed the efficacy of intradermal injection of heparin sodium in the treatment of xanthelasma and reported successful results 10,11 …”

“…However, this approach was neglected for several decades, and in the last decade, two former studies assessed the efficacy of intradermal injection of heparin sodium in the treatment of xanthelasma and reported successful results. 10,11 Hence, this work was designed to analyze the therapeutic outcomes of ablative CO 2 laser versus intradermal injection of heparin sodium in xanthelasma lesions. Following informed consent, clinical and dermoscopic assessments of xanthelasma lesions (number, size, site, and extent) were done to define the xanthelasma grading as follows 12 : Grade (Ι), if xanthelasma lesions were limited to the upper palpebral region; Grade (ΙΙ), if xanthelasma lesions were spread to the medial eye canthus; Grade (ΙΙΙ), if xanthelasma lesions were developed on the medial aspects of both upper and lower palpebral regions; and Grade (IV), if xanthelasma lesions were developed on both the medial and lateral aspects of the upper and lower palpebral regions.…”