1961
DOI: 10.1136/sti.37.2.161
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Treatment of Gonorrhoea With Phenethicillin (Broxil)

Abstract: Broxil (BRL 152), the potassium salt of 6-(x phenoxyproprionamide)-penicillanic acid (Phen-tPaper read at the European Symposium of the I.U.V.D.T. at Cracow, Poland, in September, 1960. copyright.

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Cited by 3 publications
(4 citation statements)
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“…cures with single or double dosage (Willcox, 1958) Acid-resistant Synthesized after discovery of economic source of 6-amino-penicillanic acid in fermentation broths (Batchelor, Doyle, Nayler, and Rolinson, 1959) Excellent results with 3-4 g. over 2 days (Marmell and Prigot, 1961) Indifferent results with single or double doses of 1 g. (Hilton, 1961;Allison, 1962) although 82-85 per cent. cures obtained by others (Jefferiss and Rosedale, 1961;Willcox, 1962a) Acid-resistant, broad spectrum Considered more effective than others against less sensitive strains , but others (Reyn and Bentzon, 1968) consider penicillin G and ampicillin to be equal in effectiveness weight for weight Useful clinically in penicillin G failures (Willcox, 1964a;Smith, 1966) Excellent results with multiple doses (Marmell, Sills, Brown, and Prigot, 1964;Heinemann and Vinikoff, 1965) Failure rate approx. 15 per cent.…”
Section: Oral Preparation Preferred Expensivementioning
confidence: 99%
“…cures with single or double dosage (Willcox, 1958) Acid-resistant Synthesized after discovery of economic source of 6-amino-penicillanic acid in fermentation broths (Batchelor, Doyle, Nayler, and Rolinson, 1959) Excellent results with 3-4 g. over 2 days (Marmell and Prigot, 1961) Indifferent results with single or double doses of 1 g. (Hilton, 1961;Allison, 1962) although 82-85 per cent. cures obtained by others (Jefferiss and Rosedale, 1961;Willcox, 1962a) Acid-resistant, broad spectrum Considered more effective than others against less sensitive strains , but others (Reyn and Bentzon, 1968) consider penicillin G and ampicillin to be equal in effectiveness weight for weight Useful clinically in penicillin G failures (Willcox, 1964a;Smith, 1966) Excellent results with multiple doses (Marmell, Sills, Brown, and Prigot, 1964;Heinemann and Vinikoff, 1965) Failure rate approx. 15 per cent.…”
Section: Oral Preparation Preferred Expensivementioning
confidence: 99%
“…Jefferiss and Rosedale (1961) treated 100 patients with a total dosage of 1 g. at an interval of 4 to 8 hours. There were twelve failures.…”
Section: Discussionmentioning
confidence: 99%
“…with two doses each of 0 75 g., and 12 1 per cent. with two doses each of 1 g. Jefferiss and Rosedale (1961) treated a further Summary and Conclusions (1) The need is stressed for oral therapy in gonorrhoea which will be effective in a single dose, or at the most two doses.…”
Section: Discussionmentioning
confidence: 99%
“…Elle a été découverte à la fin des années 1950 et a été utilisée au début pour les infections respiratoires hautes et basses chez les adultes et les enfants, les infections cutanées et des tissus mous, les infections dentaires et certaines infections à transmission sexuelle (ex. Neisseria gonorrhoeae) [1][2][3]…”
Section: Introductionunclassified