Treatment of Gonorrhoea With Phenethicillin (Broxil)

Jefferiss, F. J. G.; Rosedale, N.

doi:10.1136/sti.37.2.161

Cited by 3 publications

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“…cures with single or double dosage (Willcox, 1958) Acid-resistant Synthesized after discovery of economic source of 6-amino-penicillanic acid in fermentation broths (Batchelor, Doyle, Nayler, and Rolinson, 1959) Excellent results with 3-4 g. over 2 days (Marmell and Prigot, 1961) Indifferent results with single or double doses of 1 g. (Hilton, 1961;Allison, 1962) although 82-85 per cent. cures obtained by others (Jefferiss and Rosedale, 1961;Willcox, 1962a) Acid-resistant, broad spectrum Considered more effective than others against less sensitive strains , but others (Reyn and Bentzon, 1968) consider penicillin G and ampicillin to be equal in effectiveness weight for weight Useful clinically in penicillin G failures (Willcox, 1964a;Smith, 1966) Excellent results with multiple doses (Marmell, Sills, Brown, and Prigot, 1964;Heinemann and Vinikoff, 1965) Failure rate approx. 15 per cent.…”

Section: Oral Preparation Preferred Expensivementioning

confidence: 99%

A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia.

Willcox¹

1970

Sexually Transmitted Infections

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Section: Oral Preparation Preferred Expensivementioning

confidence: 99%

A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia.

Willcox¹

1970

Sexually Transmitted Infections

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“…Jefferiss and Rosedale (1961) treated 100 patients with a total dosage of 1 g. at an interval of 4 to 8 hours. There were twelve failures.…”

Section: Discussionmentioning

confidence: 99%

“…with two doses each of 0 75 g., and 12 1 per cent. with two doses each of 1 g. Jefferiss and Rosedale (1961) treated a further Summary and Conclusions (1) The need is stressed for oral therapy in gonorrhoea which will be effective in a single dose, or at the most two doses.…”

Section: Discussionmentioning

confidence: 99%

One or Two Doses of 6-(Phenoxy-proprionamide)-Penicillanic Acid (Broxil) in Acute Gonorrhoea.

Willcox¹

1962

Sexually Transmitted Infections

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Oral penicillin has a number of disadvantages in the treatment of gonorrhoea; absorption is uncertain and there is no guarantee that the patient will take the tablets in the prescribed amounts or at the proper times. If apparent cure results quickly there is also the danger that some of the tablets may be retained with a subsequent temptation towards self-medication with subcurative doses on a future occasion, and an encouragement of "black market" activity.On the other hand, the advantages are obvious for those persons who really dislike injections, and the speed of administration is much quicker if the oral route is used. Also severe penicillin reactions in allergic patients tend to be less severe when the antibiotic is given orally rather than by injection.Many of the objections to oral therapy are removed if the treatment can be administered in one single dose under supervision in the clinic. Failing this, if one dose is given in the clinic and the patient is then given a second to take after a few hours, this will probably be taken. In a previous paper (Willcox, 1958), the use of phenoxymethyl penicillin (penicillin V) in gonorrhoea was described. This penicillin given by mouth was said to produce higher and more prolonged serum levels dose for dose than had previously been possible with the available penicillin preparations. Using 2-3 mega units (1-25-1-87 g.) of penicillin V in one or two doses, there were no failures in 33 white patients, but there were 28-6 per cent. of apparent failures in 49 followed out of 52 coloured patients.Since this time there have been new developments (Lancet, 1959). Following the work in the U.S.A. of J. C. Sheehan, who first converted penicillin G to 6-aminopenicillanic acid (and who synthesised penicillin V), the English workers, Doyle

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“…Elle a été découverte à la fin des années 1950 et a été utilisée au début pour les infections respiratoires hautes et basses chez les adultes et les enfants, les infections cutanées et des tissus mous, les infections dentaires et certaines infections à transmission sexuelle (ex. Neisseria gonorrhoeae) [1][2][3]…”

Section: Introductionunclassified

Phenicillin: what (small) place for an old antibiotic in 2022?

Vaes¹,

Surin²,

Navarre³

et al. 2022

Rev Med Brux

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La phénéticilline est un ancien antibiotique de la classe des pénicillines disponible depuis mars 2022 en Belgique dans trois formulations orales différentes. La phénoxyméthylpénicilline (pénicilline V) n'étant plus sur le marché belge, la phénéticilline pourrait être un substitut pour ses indications, principalement la pharyngite à streptocoques. Ses avantages par rapport à l'amoxicilline sont un spectre plus étroit, une pression de sélection de résistance moindre et moins d'effets potentiels sur la prolifération de Candida spp et C. difficile. Les contre-indications et les précautions sont similaires à celles de la classe des pénicillines et une attention particulière doit être portée à l'administration (à jeun) et aux conditions de stockage.

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Treatment of Gonorrhoea With Phenethicillin (Broxil)

Abstract: Broxil (BRL 152), the potassium salt of 6-(x phenoxyproprionamide)-penicillanic acid (Phen-tPaper read at the European Symposium of the I.U.V.D.T. at Cracow, Poland, in September, 1960. copyright.

Cited by 3 publications

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A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia.

A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia.

One or Two Doses of 6-(Phenoxy-proprionamide)-Penicillanic Acid (Broxil) in Acute Gonorrhoea.

Phenicillin: what (small) place for an old antibiotic in 2022?

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