Treatment of gonococcal urethritis with single injections of 2-4 mega units of aqueous procaine penicillin.

Morrison, G. D.; Cobbold, R. J. C.; Bor, Serhat; Spitzer, R. J.; Foster, D. N.; Willcox, R. R.

doi:10.1136/sti.44.4.319

Cited by 13 publications

(1 citation statement)

References 18 publications

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“…A fairly common standard treatment in recent years has been by means of single injections of 1-2 mega-units of aqueous procaine penicillin but failure rates of 11 7% have been obtained in London (Wilcox, 1969) and some workers have increased the dose to 2-4 mega-units (Morrison et al, 1968) with improved results and others (Nicol et al, 1968) have indicated their intention to do so.…”

Section: Introductionmentioning

confidence: 99%

One-session treatment of gonorrhoea in males with procaine penicillin plus probenecid

Cobbold¹,

Morrison

Spitzer³

et al. 1970

Postgraduate Medical Journal

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Summary Six hundred and thirteen male patients with acute uncomplicated gonorrhoea have been treated alternately with single injections of 1·2 mega-units of aqueous procaine penicillin alone or with the same dose and preparation of penicillin with an additional 1·0 g of probenecid given orally immediately prior to injection. Whether the failure rates were assessed on the basis of an absence of further sexual exposure or by classifying all recurrences within 1 or 2 weeks regardless of history as treatment failures the results were significantly better when probenecid was also given. The use of a single dose of probenecid is thus capable of maintaining the success of single injection procedures for the treatment of gonorrhoea based on procaine penicillin and thus represents a bulwark for the future should the powers of penicillin against the gonococcus in London deteriorate further.

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Section: Introductionmentioning

confidence: 99%