Treatment of Glaucoma Using Minidrops of Clonidine

Prevention of the rise in intraocular pressure following neodymium‐YAG posterior capsulotomy using topical clonidine

“…However, studies have shown that the drop in blood pressure is small and not significant clinically (Leydhecker 1974;Harrison 1977;Rozsival 1980). Other studies demonstrated that single dose treatment did not change blood pressure and heart rate significantly (Hodapp 1981), and in others the decrease in blood pressure was found to be caused only by clonidine 0.5%, and not by clonidine 0.25% (Petursson 1984). None of our patients experienced any clinically significant systemic hypotension.…”

Prevention of the rise in intraocular pressure following neodymium‐YAG posterior capsulotomy using topical clonidine

“…However, studies have shown that the drop in blood pressure is small and not significant clinically (Leydhecker 1974;Harrison 1977;Rozsival 1980). Other studies demonstrated that single dose treatment did not change blood pressure and heart rate significantly (Hodapp 1981), and in others the decrease in blood pressure was found to be caused only by clonidine 0.5%, and not by clonidine 0.25% (Petursson 1984). None of our patients experienced any clinically significant systemic hypotension.…”

High-precision piezo-ejection Ocular microdosing: Phase II Study on Local and Systemic Effects of Topical Phenylephrine

“……”

Medications Used to Treat Glaucoma

“…When used topically, the raw clonidine molecule does lower IOP, but it also gets absorbed systemically in sufficient concentration to cause systemic hypotension. [346][347][348] Two topical alpha-adrenergic agonists are available for glaucoma therapy, apraclonidine (Iopidine) which is relatively nonselective for alpha 1 and alpha 2 receptors, and brimonidine (Alphagan and generic) that is more selective for alpha 2 than alpha 1 receptors. These drugs work by preventing the release of norepinephrine at presynaptic terminals.…”

Prevention of the rise in intraocular pressure following neodymium‐YAG posterior capsulotomy using topical clonidine

“…However, studies have shown that the drop in blood pressure is small and not significant clinically (Leydhecker 1974;Harrison 1977;Rozsival 1980). Other studies demonstrated that single dose treatment did not change blood pressure and heart rate significantly (Hodapp 1981), and in others the decrease in blood pressure was found to be caused only by clonidine 0.5%, and not by clonidine 0.25% (Petursson 1984). None of our patients experienced any clinically significant systemic hypotension.…”

High-precision piezo-ejection Ocular microdosing: Phase II Study on Local and Systemic Effects of Topical Phenylephrine

“……”

Medications Used to Treat Glaucoma

“…When used topically, the raw clonidine molecule does lower IOP, but it also gets absorbed systemically in sufficient concentration to cause systemic hypotension. [346][347][348] Two topical alpha-adrenergic agonists are available for glaucoma therapy, apraclonidine (Iopidine) which is relatively nonselective for alpha 1 and alpha 2 receptors, and brimonidine (Alphagan and generic) that is more selective for alpha 2 than alpha 1 receptors. These drugs work by preventing the release of norepinephrine at presynaptic terminals.…”

Prevention of the rise in intraocular pressure following neodymium‐YAG posterior capsulotomy using topical clonidine

“…However, studies have shown that the drop in blood pressure is small and not significant clinically (Leydhecker 1974;Harrison 1977;Rozsival 1980). Other studies demonstrated that single dose treatment did not change blood pressure and heart rate significantly (Hodapp 1981), and in others the decrease in blood pressure was found to be caused only by clonidine 0.5%, and not by clonidine 0.25% (Petursson 1984). None of our patients experienced any clinically significant systemic hypotension.…”

High-precision piezo-ejection Ocular microdosing: Phase II Study on Local and Systemic Effects of Topical Phenylephrine

“……”

Medications Used to Treat Glaucoma

“…When used topically, the raw clonidine molecule does lower IOP, but it also gets absorbed systemically in sufficient concentration to cause systemic hypotension. [346][347][348] Two topical alpha-adrenergic agonists are available for glaucoma therapy, apraclonidine (Iopidine) which is relatively nonselective for alpha 1 and alpha 2 receptors, and brimonidine (Alphagan and generic) that is more selective for alpha 2 than alpha 1 receptors. These drugs work by preventing the release of norepinephrine at presynaptic terminals.…”