Treatment of giant cell tumors of the distal radius: A long‐term patient‐reported outcomes study

Abstract

Introduction The distal radius is a common location for giant cell tumors (GCTs) of bone. Management includes intralesional curettage or wide excision, however, long‐term comparisons of treatment options are limited. The purpose of the current study was to evaluate our institutions' outcomes of treatment of these tumors. Methods We reviewed 24 GCT of the distal radius in 23 patients (12 males: 11 females) with a mean age of 42 years at the time of surgery. Functional outcomes were collected including the Musculoskeletal Tumor Society Score (MSTS), QuickDash, the Visual Analog Scale (VAS), and the Patient Rated Wrist Evaluation (PRWE). The mean follow‐up was 13 years. Results Tumor grade included Campanacci Grade II (n = 14) and Grade III (n = 10). Treatment included extended intralesional curettage (n = 16) and wide excision (n = 8). Reconstruction mainly included bone grafting/cement (n = 16) or free vascularized fibula radiocarpal arthrodesis (n = 5). At most recent follow‐up, there was no difference in MSTS, VAS, and PRWE (p > 0.05) between patients undergoing a joint sparing or arthrodesis. Patients undergoing arthrodesis had a lower QuickDASH score (13.7 vs. 20.8, p = 0.04) Conclusions Treatment for GCT of the distal radius is individualized however in the setting of articular surface involvement, arthrodesis can lead to superior functional results at long‐term follow‐up.

Cuboid Bone for Distal Radius Reconstruction: An Anatomical Study by 3D Models

“…Although many different techniques have been described, the optimal reconstruction remains controversial. [10][11][12][13][14][15][16][17] Autologous reconstruction would be a suitable option for active, young patients for whom we would like to delay a prosthetic replacement or avoid a wrist arthrodesis procedure. 18 Vascularized foot bone transfer for DRUJ reconstruction is a procedure recently described in the literature.…”

The optimal strategy for 3D‐printed uncemented endoprosthesis for the bone defect reconstruction of the distal radius, based on biomechanical analysis and retrospective cohort study

“…The distal radius is a relatively unusual site for bone tumors, among which giant cell tumor of bone (GCTB) is the most common. [1][2][3] For patients with Campanacci grade III or recurrent GCTB of the distal radius, en bloc resection is recommended. 1,4 However, it is challenging for surgeons to reconstruct the segmental defects after tumor resection because of the high functional requirements of the wrist joint, the relatively insufficient soft tissue coverage, and the close relationship with the surrounding vasculature, nerves, and tendons.…”

“…The distal radius is a relatively unusual site for bone tumors, among which giant cell tumor of bone (GCTB) is the most common 1–3 . For patients with Campanacci grade III or recurrent GCTB of the distal radius, en bloc resection is recommended 1,4 .…”

Siglec-15 as a New Perspective Therapy Target in Human Giant Cell Tumor of Bone

“…A GCTB is mainly detected in young adults between 20 and 40 years old [ 8 ]. Adjuvants, including phenol and methyl methacrylate, have been applied in GCTB surgical treatments, but the recurrence rate is still high (25–50%) [ 9 , 10 , 11 , 12 , 13 ]. Presently, though Denosumab has dramatically changed the treatment paradigm for a GCTB, which will be highly efficacious and well tolerated, there is still a chance that osteonecrosis of the jaw and rebound hypercalcemia occurred in GCTB patients [ 14 ].…”