“…There are currently extensive international data on thousands of healthy children and children with numerous pediatric chronic health conditions published or in press in over 320 peer-reviewed journals since 2001 (A full listing of the updated peer-reviewed journal publications is available at www.pedsql.org). The PedsQL 4.0 Generic Core Scales has been shown to distinguish between healthy children and children with pediatric chronic health conditions, has demonstrated sensitivity to disease severity and responsiveness through patient change over time, and evidenced significant intercorrelations with disease-specific symptom scales (Bastiaansen et al 2004a, b;Chan et al 2005;Crabtree et al 2004;Felder-Puig et al 2004;Powers et al 2004;Razzouk et al 2004;Schwimmer et al 2003;Upton et al 2005;Uzark et al 2003;Varni et al 2001Varni et al , 2002aVarni et al , b, c, 2003aVarni et al , b, 2004aWilliams et al 2005;Youssef et al 2004). Further, the PedsQL 4.0 has been shown to have an impact on clinical decision-making (de Wit et al 2008;Seid et al 2001Seid et al , 2004aVarni et al 2002b, c).…”