Treatment of frozen shoulder with subcutaneous TNF-alpha blockade compared with local glucocorticoid injection: a randomised pilot study

Schydlowsky, Pierre; Szkudlarek, Marcin; Madsen, Ole Rintek

doi:10.1007/s10067-012-1993-5

Cited by 13 publications

(12 citation statements)

References 12 publications

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“…99 Although the use of anti-TNF agents in autoimmune and inflammatory disorders is well-documented, its application in the treatment of adhesive capsulitis has not been well-studied. In one randomized pilot study, Schydlowsky et al 100 demonstrated no efficacy of subcutaneous injection of adalimumab in the treatment of adhesive shoulder capsulitis.…”

Section: Operative Managementmentioning

confidence: 99%

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Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments

et al. 2016

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Adhesive shoulder capsulitis, or arthrofibrosis, describes a pathological process in which the body forms excessive scar tissue or adhesions across the glenohumeral joint, leading to pain, stiffness and dysfunction. It is a debilitating condition that can occur spontaneously (primary or idiopathic adhesive capsulitis) or following shoulder surgery or trauma (secondary adhesive capsulitis). Here, we review the pathophysiology of adhesive shoulder capsulitis, highlighting its clinical presentation, natural history, risk factors, pathoanatomy and pathogenesis. Both current non-operative and operative treatments for adhesive capsulitis are described, and evidence-based studies are presented in support for or against each corresponding treatment. Finally, the review also provides an update on the gene expression profile of adhesive capsulitis and how this new understanding can help facilitate development of novel pharmacological therapies.

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Section: Operative Managementmentioning

confidence: 99%

“…In one randomized pilot study, Schydlowsky et al. 100 demonstrated no efficacy of subcutaneous injection of adalimumab in the treatment of adhesive shoulder capsulitis.…”

Section: Reviewmentioning

confidence: 99%

Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments

et al. 2016

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“…Subcutaneous TNF-α blockers Because of a lack of efficacy and excessive side effects, a study evaluating the subcutaneous injection of the TNF-α blocker adalimumab to treat shoulder stiffness was interrupted [41].…”

Section: Other Treatment Approachesmentioning

confidence: 99%

Shoulder Stiffness – How to Treat?

et al. 2019

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Shoulder stiffness is a condition of restricted glenohumeral range of motion, which can arise spontaneously or as consequence of a known cause, including surgical procedures on the shoulder. Several approaches to shoulder stiffness have been proposed and high-level evidence is available to analyze and discuss their results. The aim of this review was to summarize the current concepts on conservative and operative treatment of shoulder stiffness and discuss the results of the available studies with a high level of evidence, which should be considered to guide clinical practice. Treatment of shoulder stiffness should be tailored to the patientʼs clinical situation and the stage of its shoulder pathology and should aim at pain reduction, restoration of range of motion, functional regain and shortening of symptoms duration. When possible, known risk factors for primary shoulder stiffness and causes of secondary shoulder stiffness should be addressed to avoid relapse. Conservative therapy is the mainstay of treatment for shoulder stiffness and should include a multimodal and activity-oriented program. Intra-articular injection of a low dose of corticosteroid is safe and effective, provides immediate benefits, and is recommended in combination to an appropriate rehabilitation protocol. In conservative refractory cases, arthrolysis and capsular release can be performed with an arthroscopic approach.

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“…11 The condition can last up to 5 years. 12 Treatment is based on the disease stage and might include physiotherapy, intra-articular steroids, hydrodilatation, manipulation under anaesthesia, or arthroscopic capsular release.…”

Section: Introductionmentioning

confidence: 99%

“…Treatments may reduce the duration or severity of symptoms, but are generally unable to restore function quickly. 12 However, symptoms may resolve spontaneously at any stage. 13 The pathological features of AC are thought to arise from the combined effects of inflammation and fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic analysis of adhesive capsulitis of the shoulder

Kamal

McGee

Eng

et al. 2020

Journal Orthopaedic Research

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Adhesive capsulitis (AC) is a disabling condition of the shoulder joint affecting 2 to 5% of the general population. Our understanding of the molecular mechanisms is limited. The present study aimed to determine potential biomarkers of AC through transcriptomic analysis. This multi‐centre study investigated patients undergoing arthroscopic capsulotomy surgery for resistant AC compared to those undergoing arthroscopic stabilization surgery for glenohumeral instability (control). Tissue samples were harvested from the anterior capsule during surgery. Total RNA was extracted and RNA‐sequencing‐based transcriptomics were performed. A number of genes deemed differentially expressed in RNA‐sequencing analysis were validated using real‐time reverse transcription polymerase chain reaction (RT‐PCR). Baseline characteristics of the AC group (n = 22) were; mean age 52.7 years (SD: 10.2), 73% female, and Oxford Shoulder Score 19.6 (SD: 8.0), compared with the control group (n = 26), average age 23.9 years (SD: 5.2), 15% female, and Oxford Shoulder Score 39.0 (SD: 7.4). Transcriptomic analysis with false discovery rate correction and log2 fold change cut‐off of ±1.5 revealed 545 differentially expressed genes in AC relative to control. Bioinformatic analyses were carried out to identify biological processes and pathways enriched in this dataset. Real‐time RT‐PCR using two different normalization processes confirmed increased expression of matrix metallopeptidase 13 (MMP13) and platelet‐derived growth factor subunit B (PDGFB), in patients with AC, while tumor necrosis factor α (TNFA) expression was reduced. These findings provide a comprehensive assessment of transcriptional changes associated with AC that give insights into the aetiology of the disease and provides a resource for molecular targets to better diagnose and treat this condition.

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Treatment of frozen shoulder with subcutaneous TNF-alpha blockade compared with local glucocorticoid injection: a randomised pilot study

Cited by 13 publications

References 12 publications

Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments

Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments

Shoulder Stiffness – How to Treat?

Transcriptomic analysis of adhesive capsulitis of the shoulder

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