Treatment of fetal supraventricular tachycardia with maternal administration of digoxin

Transplacental digoxin therapy for fetal tachyarrhythmia with multiple evaluation systems

“…Based on these results, we recommend increasing the initial dosage to obtain a faster rhythm conversion. It was reported that cardiac conversion rate of digoxin monotherapy for fetal AF was in a range of 50-88% [11,19], 71% for non-hydropic, and 41% for hydropic fetal SVT [12,20]. Fortunately, all of the four cases in this report (100%) achieved cardiac conversion after digoxin therapy, which was a relatively higher success rate.…”

“…However, it took 10 and 42 days, respectively, for two AF cases to achieve the conversion of AF to sinus rhythm, which is relatively longer than that of two SVT cases, as well as the previously reported time (approximately 1 week) [11][12][13][14]. In addition, we observed that when the dosage of digoxin is increased to 0.25 mg q12h, the time for rhythm conversion is much shorter.…”

“…Previous literature [7,8,[11][12][13] revealed that digoxin represents the first-line agents for fetal tachycardia and heart failure with the advantages of high efficacy of placental transportation and low retention. The recommended dosage of oral digoxin for gravida is 0.2 mg bid to qid.…”