Treatment of febrile seizures

Guerreiro, Marilisa M.

doi:10.2223/jped.845

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…A low threshold, probably initiated from a combination between increased excitation and reduced inhibition, in addition to other maturational differences in subcortical circuits. 8 Vaccines and febrile seizures have a strong association, both febrile and afebrile seizures can happen after immunization. 6,7,9 A significant association was found between Iron deficiency anemia and febrile seizures.…”

Section: Pathophysiologymentioning

confidence: 99%

Role of serum sodium levels in recurrence and recurrent episodes of febrile seizure

Benny¹

2020

Int J Contemp Pediatr

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Background: Simple febrile seizures are the common childhood seizures, usually affecting 1 in 20 children between the age group of 6 months to 60 months. Earlier studies have shown an association between low serum sodium as a cause for febrile seizures and its recurrences. The present study was to determine the role of serum sodium in predicting febrile seizure recurrence within 24 hrs and recurrent episodes.Methods: Children aged between 6 months to 60 months with first episode of febrile seizures, admitted to the Paediatric ward of MOSC medical college Kolenchery, were recruited in the study. Inclusion criteria were demographic data, family history, clinical examinations, and laboratory investigations (serum sodium and hemoglobin).Results: Of the total study population of 100 children 33 had recurrences in 24 hours and 16 had recurrent episodes. About 57 children had a family history of febrile seizures, out which 28 children had recurrence of febrile seizure within 24 hours. 26 children had family history of epilepsy, of which only 8 had recurrences in 24 hours and 5 had recurrent episodes. Serum sodium levels of 69 children was above 130 mmol/l and 31 children had sodium level below 130mmol/l. Of 31 children, with low serum sodium levels (<130mmol/l), 29 had recurrence within 24 hours, which was not statistically significant. The sodium levels of 16 children who had recurrent episodes of seizure, was also between 130.1-135mmol/. No significant differences were seen between the serum sodium levels in simple febrile seizures and recurrent episodes.Conclusions: Study showed low serum sodium is not statistically significant to predict a recurrence within 24 hours, but a relative hyponatremia can predispose, a febrile child to occurrence of simple febrile seizure.

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Section: Pathophysiologymentioning

confidence: 99%

Role of serum sodium levels in recurrence and recurrent episodes of febrile seizure

Benny¹

2020

Int J Contemp Pediatr

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“…Approximately 2-5% of children are estimated to experience at least 1 epileptic seizure during a febrile illness before they are 5 yr old. The incidence of febrile seizures varies between 2% and 4% in Western countries, whereas the incidence is 7% in Japan and higher in developing countries [2-4]. …”

Section: Introductionmentioning

confidence: 99%

Comparison of Serum Zinc Levels Measured by Inductively Coupled Plasma Mass Spectrometry in Preschool Children with Febrile and Afebrile Seizures

Lee

Kim

2012

Ann Lab Med

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BackgroundChanges in levels of trace elements have been proposed to underlie febrile seizures. Particularly, low zinc levels have been proposed as related factor of febrile seizure. In this study, we investigated whether mean serum zinc levels differed between children with febrile seizure and afebrile seizure.MethodsUsing inductively coupled plasma mass spectrometry, serum zinc levels were measured in 288 children who had been diagnosed with febrile seizures (N=248) and afebrile seizures (N=40). Mean serum zinc levels were compared between the 2 groups.ResultsMean serum zinc level was 60.5±12.7 µg/dL in the febrile seizure group and 68.9 ±14.5 µg/dL in the afebrile seizure group. A significant difference in serum zinc levels was observed between the febrile and afebrile seizure groups (P<0.001).ConclusionsZinc levels in children with febrile seizure were significantly lower than those in children with afebrile seizure.

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“…However, a variety of factors are considered to be involved in pathogenesis of febrile seizure such as genetic factors, 1 family backgrounds, 2 iron deficiency 3,4 immunologic disorders 7 and zinc deficiency. 5,6 Limited numbers of studies have been conducted regarding the role of zinc in occurrence of febrile seizures.…”

Section: Discussionmentioning

confidence: 99%

“…But electrolyte imbalance, hereditary metabolic disorder, genetic factor; neurologic problem, and iron deficiency, immunologic problem and zinc deficiency may play a role in febrile seizure. [3][4][5] Zinc one of the most important elements in the body that is necessary to abundance in central brain system can be found on the division and distinction between cells that is effective will eventually lead to a brain system will be natural. More on cheap in the brain are connected to that role very important construction and functional .it is also an important cofactor for different enzyme such as DNA and RNA polymerases.…”

Section: Introductionmentioning

confidence: 99%

Comparison of serum zinc in children younger than 5 years old with febrile convulsion, children with seizures without fever and normal children

Torabinejad

Shamspour

et al. 2014

Int J Res Med Sci

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Treatment of febrile seizures

Cited by 3 publications

References 36 publications

Role of serum sodium levels in recurrence and recurrent episodes of febrile seizure

Role of serum sodium levels in recurrence and recurrent episodes of febrile seizure

Comparison of Serum Zinc Levels Measured by Inductively Coupled Plasma Mass Spectrometry in Preschool Children with Febrile and Afebrile Seizures

Comparison of serum zinc in children younger than 5 years old with febrile convulsion, children with seizures without fever and normal children

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