Treatment of Facial Fat Atrophy Related to Treatment with Protease Inhibitors by Autologous Fat Injection in Patients with Human Immunodeficiency Virus Infection

Serra-Renom, José María; Fontdevila, Joan

doi:10.1097/01.prs.0000128427.54445.63

Cited by 65 publications

(32 citation statements)

References 3 publications

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“…Desde hace algunos años utilizamos los injertos de grasa para el remodelamiento facial, bien como tratamiento único o asociado al estiramiento facial sobre todo para la remodelación de la región malar y de los pómulos (1,2). Actualmente añadimos a estos injertos grasos Factores de Crecimiento Plaquetario (F.C.P.)…”

Section: Introductionunclassified

Uso de factores de crecimiento plaquetar unidos a injertos de grasa para lipofiling facial en ritidectomía

Renom

Olmo²,

Caballero³

2006

Cir. Plást. Iberlatinamer.

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Platelet -derived growth factors. Código numérico 15841Palabras clave Injertos grasos faciales. Plasma rico en plaquetas. Factores de crecimiento plaquetario. Código numérico 15841Presentamos una serie de pacientes a los que hemos realizado infiltraciones de grasa enriquecida con Factores de Crecimiento Plaquetario (F.C.P.) como único procedimiento. Igualmente presentamos casos donde las infiltraciones van acompañadas con otros procedimientos (lifting temporal, lifting cérvico-frontal, etc.). También usamos el plasma rico en F.C.P. en forma de coágulo para rellenar el surco de la cuenca orbitaria ("Tear Through"), y como mesoterapia facial enriquecida con nutrientes.El objetivo de este trabajo es presentar una revisión detallada de los pasos a seguir para la realización de éste procedimiento, que van desde la simple extracción de sangre para la posterior obtención de F.C.P. hasta la téc-nica de infiltración de grasa enriquecida con dichos factores a nivel facial.Con esta técnica de enriquecimiento de la grasa hemos logrado tener mejores resultados y con mayor permanencia. Evaluando los postoperatorios de pacientes sometidos a este procedimiento, hemos observado que el volumen infiltrado en áreas como la región malar, se mantiene entre un 90% a 95%. En otras áreas como labios y surcos nasogenianos (áreas de gran movilidad), solo permanece entre el 50% a 60% del volumen infiltrado. We present a serie of patients with facial fat infiltration enriched with platelet-derived growth factors, some of them associated to other surgical procedures (temporal lifting, cervico-frontal lifting, etc.) We explain how to use this platelet -rich plasma to fill the tear -through and as a facial mesotherapy.Our purpose is to present a detailled review of our method: since blood extraction to the last obtention of the platelet -derived growth factors and the use of this plasma combined with fat infiltration in the facial area. With this methodology we have got better and more permanent results. We have evaluated 90-95 % fat grafts survival in malar region. In other facial areas such as lips or nasogenian folds (big movement areas), we only report about 50 to 60% fat graft survival. Serra Renom, J. M.

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Section: Introductionunclassified

Uso de factores de crecimiento plaquetar unidos a injertos de grasa para lipofiling facial en ritidectomía

Renom

Olmo²,

Caballero³

2006

Cir. Plást. Iberlatinamer.

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“…Growth Factors (GF) are polypeptides of amino acids that form a globular protein and belong to the group of cytokines. They are produced in greater quantities by macrophages and platelets (19,20) . These cytokines have the ability to join cell membrane receptors that activate or inhibit cellular functions by target cells on which they act.…”

Section: Healing and Growth Factorsmentioning

confidence: 99%

Advanced Lipotransfer Techniques

Blugerman¹,

Amar²,

Schavelzon³

et al. 2011

Advanced Techniques in Liposuction and Fat Transfer

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“…Autologous fat injections or dermal fat grafts have been reported to be successful [9,10,11,12] but these techniques may require multiple sessions and intravenous sedation or even general anesthesia. In addition, the donor areas of patients with HIV are limited due to the marked effect of lipoatrophy, and the injected fat may be lost due to continuation of the lipoatrophic process.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Experiences with Bio-Alcamid in HIV Facial Lipoatrophy

2007

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Background: Highly active antiretroviral therapy for HIV-infected patients causes metabolic changes known as the lipodystrophy syndrome. Autologous fat injections, dermal fat grafts, malar implants and injected fillers have been reported as treatment options. Objective: To evaluate the results of HIV-infected patients treated with Bio-Alcamid for facial lipoatrophy. Methods and Materials: Over a 3-year period, 13 HIV-infected patients with facial lipoatrophy had Bio-Alcamid injections for aesthetic purposes. The procedure was done under local anesthesia, and the amount of the injected material varied from 5 to 13 ml. Results were independently evaluated by patients and physicians. Results: Most of the patients felt they had good to excellent results. Touch-ups were necessary for 2 patients; the added volume was 2–3 ml for each. No major complications were recorded. A small hematoma was noted in 1 patient. Overcorrection was attained in 2 cases, and some of the filler was removed at the patient’s request. Conclusion: One of the greatest advantages of this filler is that, although permanent, it can be removed easily. We consider Bio-Alcamid to be a safe and useful correcting tool for patients suffering from drug-induced facial lipoatrophy.

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Treatment of Facial Fat Atrophy Related to Treatment with Protease Inhibitors by Autologous Fat Injection in Patients with Human Immunodeficiency Virus Infection

Cited by 65 publications

References 3 publications

Uso de factores de crecimiento plaquetar unidos a injertos de grasa para lipofiling facial en ritidectomía

Uso de factores de crecimiento plaquetar unidos a injertos de grasa para lipofiling facial en ritidectomía

Advanced Lipotransfer Techniques

Preliminary Experiences with Bio-Alcamid in HIV Facial Lipoatrophy

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