Treatment of Exuberant Granulation Tissue in the Horse Evaluation of Four Methods

Abstract

Four methods of treating granulating wounds on the dorsal aspect of the metacar‐pophalangeal and metatarsophalangeal joints of ponies were evaluated. The following treatments were used: Group 1—excision of the granulation tissue with no further treatment; Group 2—cryosurgery; Group 3—excision of the granulation tissue and pressure bandage; and Group 4—excision of the granulation tissue and immobilization of the limb with a plaster cast. The wounds in Group 1 healed fastest, without producing exuberant granulation tissue and with only moderate scar fibrosis. The wounds in Group 2 healed without producing exuberant granulation tissue but with marked scarring. Wounds in Groups 3 and 4 took longer (p < 0.001) to heal compared to wounds in Groups 1 and 2. Wounds in Groups 3 and 4 produced exuberant granulation tissue, but the resultant scars were the least fibrotic.

Factors regulating collagen synthesis and degradation during second-intention healing of wounds in the thoracic region and the distal aspect of the forelimb of horses

“…Second-intention healing of wounds in the distal portion of the limbs is more complicated in horses than in other domestic species as a result of several factors, including minimal blood supply to the distal portion of the limbs, minimal amounts of underlying soft tissues, hypoxia, inability to immobilize the area, lack of cutaneous musculature, and infection or chronic inflammation. [1][2][3][4] Other complications associated with second-intention healing in this location include indolent wounds, hypergranulating wounds, and formation of sarcoids. 5 Wounds heal by contraction and epithelialization.…”

Growth Characteristics of Fibroblasts Isolated From the Trunk and Distal Aspect of the Limb of Horses and Ponies

“…Several studies have reported differences in the amount of exuberant granulation tissue produced by horses and ponies 2,3 . There is also a difference in the quantity and rate of formation of exuberant granulation tissue produced between trunk and limb wounds 2,3 . In horses, wounds on the distal aspect of the limb produce more exuberant granulation tissue than trunk wounds.…”

Equine wound healing: influence of low level laser therapy on an equine metacarpal wound healing model

“…There have been countless topical preparations and medications that have been applied to DLWs over the millennia and even in recent times, but few have actually been scientifi cally shown to possess signifi cant clinical effi cacy. There have been numerous studies comparing treatments such as corticosteroids [4] , platelet rich plasma [5] , occlusive dressings [6] , and collagen gel [7] , growth factors [8] and immobilization [9] , but no treatment has been shown to have a statistically significant effect on the healing rate of full thickness excisional skin wounds. The goals of treating DLWs include minimizing exuberant granulation tissue and facilitating contraction and epithelialization.…”