Treatment of experimental immune complex glomerulonephritis by sodium alginate

Mirshafiey, Abbas; Borzooy, Zohreh; Abhari, Reza S.; Razavi, Alireza; Tavangar, Seyed Mohammad; Rehm, Bernd H. A.

doi:10.1016/j.vph.2005.03.002

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…Alginate has been suggested to activate monocytes and macrophages, potentially via the NF-κβ pathway [18,19,24–26], and several studies have reported the detection of antibodies against alginate in vivo [27–29]. Conflicting with this, alginate has been used as an anti-inflammatory to suppress experimental glomerulonephritis and ulcerative colitis [20,30]. The literature on alginate immunogenicity is abundant yet controversial, and many of these results must be interpreted with caution as alginates used in past studies may have contained impurities such as endotoxins, residual proteins or polyphenols, all of which affect the immunogenicity of alginate [21,31–33].…”

Section: Discussionmentioning

confidence: 99%

Ca2+ released from calcium alginate gels can promote inflammatory responses in vitro and in vivo

Chan

Mooney

2013

Acta Biomaterialia

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In general, alginate hydrogels are considered to be biologically inert and are commonly used for biomedical purposes that require minimum inflammation. However, Ca2+, which is commonly used to crosslink alginate, is a critical second messenger in immune cell signaling, and little has been done to understand its effect on immune cell fate when delivered as a component of alginate gels. We found that dendritic cells (DCs) encapsulated in Ca2+-crosslinked alginate (calcium alginate) secreted at least fivefold more of the inflammatory cytokine IL-1β when compared to DCs encapsulated in agarose and collagen gels, as well as DCs plated on tissue-culture polystyrene (TCPS). Plating cells on TCPS with the alginate polymer could not reproduce these results, whereas culturing DCs on TCPS with increasing concentrations of Ca2+ increased IL-1β, MHC class II and CD86 expression in a dose-dependent manner. In agreement with these findings, calcium alginate gels induced greater maturation of encapsulated DCs compared to barium alginate gels. When injected subcutaneously in mice, calcium alginate gels significantly upregulated IL-1β secretion from surrounding tissue relative to barium alginate gels, and similarly, the inflammatory effects of LPS were enhanced when it was delivered from calcium alginate gels rather than barium alginate gels. These results confirm that the Ca2+ used to crosslink alginate gels can be immunostimulatory and suggest that it is important to take into account Ca2+’s bioactive effects on all exposed cells (both immune and non-immune) when using calcium alginate gels for biomedical purposes. This work may strongly impact the way people use alginate gels in the future as well as provide insights into past work utilizing alginate gels.

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Section: Discussionmentioning

confidence: 99%

Ca2+ released from calcium alginate gels can promote inflammatory responses in vitro and in vivo

Chan

Mooney

2013

Acta Biomaterialia

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“…The method of Yamamoto et al previously described by Mirshafiey et al was performed. 15 Eight weeks after s.c. immunization with 1 mg of BSA (Sigma Aldrich, Istanbul, Turkey) in complete Freund's adjuvant, an i.v. dose of 2 mg BSA (in 1 mL 0.9% saline) daily for 28 days was administrated.…”

Section: Induction Of Immune-complex Glomerulonephritismentioning

confidence: 99%

Decrease in cell proliferation by an matrix metalloproteinase inhibitor, doxycycline, in a model of immune‐complex nephritis

Sağlam¹,

Celik²,

Tayfur³

et al. 2010

Nephrology

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“…Previous studies documented that LvSA treatment significantly reduce the urinary protein excretion and serum creatinine as well as vanquish the progression of glomerular lesions in immune complex glomerulonephritis. 11 Moreover, the protective and reparative effects of sodium alginate on radiation stomatitis and suppression of radioactive absorption by this compound in animals and human subjects were investigated. In addition, it is also documented to attenuate hypertension, associated kidney damage.…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective Effect of Low Viscosity Sodium Alginate on Lead Acetate-Induced Nephrotoxicity in Rats

Kaur¹,

Sharma²

2017

IJPER

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Objective: Renal failure in majority of population is considered to be idiopathic. Heavy metals like lead in drinking water are usually the hidden cause of these renal consequences. Thus, this study has been designed to investigate the effect of low viscosity sodium alginate (LvSA) in Lead-induced nephrotoxicity. Methods: Lead (0.2% lead acetate in drinking water for 5 weeks) was administered in rats to produce nephrotoxicity assessed in terms of histopathological changes, increase in serum creatinine, blood urea nitrogen, urinary N-acetyl-β D glucosaminidase (NAG), proteinuria, Thiobarbituric acid reactive substances (TBARS) and decrease in reduced glutathione level. Results : Lead acetate (LA) intoxication shown elevations in serum creatinine, Proteinuria, glomerular filtration rate (GFR), blood urea nitrogen (BUN), Thiobarbituric acid reactive substances (TBARS), altered urinary N-acetyl-β D glucosaminidase (NAG), kidney weight/ body weight ratio (KW/BW %), and creatinine clearance that indicate renal damage. Treatment with Low viscosity sodium alginate (LvSA) show significant decrease in serum creatinine, BUN, urinary NAG, protein in urine, KW/BW %, TBARS level and increase in GSH, creatinine clearance and GFR. Conclusion: Thus, on the basis of results it may be concluded that LvSA significantly attenuated Lead-induced nephrotoxicity.

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Treatment of experimental immune complex glomerulonephritis by sodium alginate

Cited by 11 publications

References 27 publications

Ca2+ released from calcium alginate gels can promote inflammatory responses in vitro and in vivo

Ca2+ released from calcium alginate gels can promote inflammatory responses in vitro and in vivo

Decrease in cell proliferation by an matrix metalloproteinase inhibitor, doxycycline, in a model of immune‐complex nephritis

Nephroprotective Effect of Low Viscosity Sodium Alginate on Lead Acetate-Induced Nephrotoxicity in Rats

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