Treatment of established osteoporosis and rehabilitation: current practice and possibilities

Dequeker, Jan; Geusens, Piet

doi:10.1016/0378-5122(90)90057-d

Maturitas

1990

DOI: 10.1016/0378-5122(90)90057-d

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Treatment of established osteoporosis and rehabilitation: current practice and possibilities

Jan Dequeker

Piet Geusens

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1993

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Cited by 4 publications

(1 citation statement)

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“…Ideally this situation should be preventable, but the preventive therapy has not been without side effects (Dequeker and Geusens, 1990). To decrease bone fragility in developed osteoporosis, the optimal choice is to increase bone volume of good quality.…”

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confidence: 99%

Short‐term oral phosphate and bone remodeling in beagles

Shih

Anderson

1993

Anat. Rec.

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Attempts to increase bone volume in osteoporotic patients are still in the experimental stage. The coherence therapy, proposed by Frost, suggests that the activated bone units can remodel bone matrix in tandem. The cells (i.e., osteoclast and osteoblast which compose the remodeling units) are manipulated through specific medications timed to each of their duration of actions. The current study was to examine the effect of withdrawal of oral phosphate on bone in ovariectomized dogs. The present report demonstrates the capability of short-term oral phosphate to activate bone remodeling in the ovariectomized animal model. Results from biochemical and histomorphometric analyses confirm that remodeling units are activated following the release of parathyroid hormone. This transient scenario inflicts a shift of mineral density distribution in cancellous bone matrix of the iliac crest. Nevertheless, the bone remodeling units appear to be synchronized with each other and thus their resorptive and formative phases should be amenable to further pharmacological manipulation.

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confidence: 99%

Short‐term oral phosphate and bone remodeling in beagles

Shih

Anderson

1993

Anat. Rec.

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Efficacy of ipriflavone and 1α vitamin D therapy for the cessation of vertebral bone loss

Ushiroyama

Okamura

Ikeda

et al. 1995

Intl J Gynecology & Obste

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Osteoporosis

Duursma

Raymakers

Scheven

et al. 1993

Rev. Clin. Gerontol.

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Treatment of established osteoporosis and rehabilitation: current practice and possibilities

Cited by 4 publications

References 107 publications

Short‐term oral phosphate and bone remodeling in beagles

Short‐term oral phosphate and bone remodeling in beagles

Efficacy of ipriflavone and 1α vitamin D therapy for the cessation of vertebral bone loss

Osteoporosis

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