Treatment of erythema migrans with doxycycline for 7 days versus 14 days in Slovenia: a randomised open-label non-inferiority trial

Stupica, Daša; Collinet-Adler, Stefan; Blagus, Rok; Gomišček, Anja; Kišek, Tjaša Cerar; Ružić‐Sabljić, Eva; Velušček, Maša

doi:10.1016/s1473-3099(22)00528-x

Cited by 12 publications

(5 citation statements)

References 26 publications

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“…10 The results of several randomized controlled trials (RCTs) support the use of shorter antibiotic durations in comparison to traditional courses in a variety of infections, 11 with a recent study showing non-inferiority in treating Lyme disease with 7 days of doxycycline compared with 14 days. 12 Furthermore, the benefits of a shorter antibiotic course extend beyond preserving future antibiotic efficacy, including cost-efficiency, convenience, potentially encouraging better adherence, and protecting individuals from harm caused by unnecessary antibiotics.…”

Section: Discussionmentioning

confidence: 99%

“…In an era where STI rates continue to rise and evolving antimicrobial resistance is threatening effective management of infections globally, it is vital for clinicians to review treatment guidelines to rationalize antibiotic use and recommend the shortest effective antibiotic course possible 10 . The results of several randomized controlled trials (RCTs) support the use of shorter antibiotic durations in comparison to traditional courses in a variety of infections, 11 with a recent study showing non-inferiority in treating Lyme disease with 7 days of doxycycline compared with 14 days 12 . Furthermore, the benefits of a shorter antibiotic course extend beyond preserving future antibiotic efficacy, including cost-efficiency, convenience, potentially encouraging better adherence, and protecting individuals from harm caused by unnecessary antibiotics.…”

Section: Discussionmentioning

confidence: 99%

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Effective treatment of lymphogranuloma venereum with a seven-day course of doxycycline

Bilinska,

Artykov,

White

2024

Sexual Trans Dis

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Effective treatment of lymphogranuloma venereum with a seven-day course of doxycycline Background Lymphogranuloma venereum (LGV) remains endemic in the United Kingdom, primarily among gay, bisexual or other men who have sex with men (GBMSM). Current treatment guidelines recommend twenty-one days of doxycycline, but recent evidence suggests shorter antibiotic duration is as effective. We evaluated clinical outcomes in a cohort with LGV treated with seven days of doxycycline. Methods We reviewed case notes of all LGV cases at a South London sexual health service between November 2016 and September 2022, treated with only seven days of doxycycline and anonymised data were collected from electronic patient records. Results Fifty-two individuals with detected LGV-specific DNA were treated with seven days of doxycycline 100 mg twice daily. All were GBMSM, median age 35 years (range 21-64); 21 (40%) were living with HIV; and 18 (35%) had concomitant sexually transmitted infections. Thirty-four (65%) were asymptomatic, while 18 (35%) reported symptoms: 7 (13%) urethral, 11 (21%) anorectal, and 2 (4%) other symptoms. Twenty-two (42%) were prescribed additional antimicrobials, however none were active against Chlamydia trachomatis. All 52 underwent follow-up testing (range 4 – 481 days); C. trachomatis was detected in one individual, but negative for LGV-specific DNA, and so considered to be a reinfection. All other cases were C. trachomatis negative, indicating successful LGV eradication. Conclusions Our data support the approach of offering a seven-day doxycycline course routinely for asymptomatic or clinically mild C. trachomatis infections, and contacts of LGV infection, regardless of their LGV status. This may simplify patient management, reduce cost and improve antimicrobial stewardship.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effective treatment of lymphogranuloma venereum with a seven-day course of doxycycline

Bilinska,

Artykov,

White

2024

Sexual Trans Dis

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“…In patients with myalgia, headache, and persistent fatigue after a tick bite, infection with SFG rickettsiae should be suspected, tested, and possibly treated, unless they have already received adequate therapy. In patients with early Lyme disease, in whom antibody testing for SFG rickettsiae and A. phagocytophilum was not performed, tetracyline (specifically doxycycline) should be considered as first-line therapy after a tick bite to treat possible infection with SFG rickettsiae and A. phagocyophilum [ [32] , [33] , [34] ].…”

Section: Discussionmentioning

confidence: 99%

Spotted fever group rickettsiae and Anaplasma phagocytophilum in Borrelia burgdorferi sensu lato seropositive individuals with or without Lyme disease: A retrospective analysis

Kosak¹,

Satz²,

Jutzi³

et al. 2023

New Microbes and New Infections

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“…Selbst beim Auftreten von multiplen EM ist eine 14tägige orale Doxycyclintherapie einer i. v.-Antibiose gleichwertig [29]. Bei EM ist nach neueren Studiendaten eine 7-tägige Doxycyclintherapie einer 14-tägigen Applikation nicht unterlegen [30]. Daten in Bezug auf die Wirksamkeit von Penicillin bei Lyme-Arthritis sind z.T.…”

Section: Therapie Der Lyme-borrelioseunclassified

Lyme-Borreliose und Lyme-Arthritis

Keyßer

2024

Aktuelle Rheumatologie

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ZusammenfassungDie Lyme-Arthritis stellt eine Übergangsform zwischen infektiös-bakteriellen und reaktiven Arthritiden dar. Auslöser sind Borrelien, eine aus mehreren Unterarten bestehende Spezies aus der Familie der Spirochäten. Die Erreger werden i.d.R. durch Stiche der Schildzecken-Gattung Ixodes übertragen und verursachen akute und chronische Manifestationen an Haut, Nervensystem, Gelenken und – seltener – an inneren Organen. Die Behandlung der akuten Lyme-Arthritis erfolgt durch Antibiotika wie Doxycyclin, Amoxizillin und Ceftriaxon. Die chronische Lyme-Arthritis nach erfolgloser Antibiotikatherapie ist ein vielschichtiges, schlecht charakterisiertes und umstrittenes Krankheitsbild, welches in erster Linie Anlass zur Überprüfung der Diagnose geben sollte. Von multiplen Antibiotikazyklen profitieren die Betroffenen nicht.

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Treatment of erythema migrans with doxycycline for 7 days versus 14 days in Slovenia: a randomised open-label non-inferiority trial

Cited by 12 publications

References 26 publications

Effective treatment of lymphogranuloma venereum with a seven-day course of doxycycline

Effective treatment of lymphogranuloma venereum with a seven-day course of doxycycline

Spotted fever group rickettsiae and Anaplasma phagocytophilum in Borrelia burgdorferi sensu lato seropositive individuals with or without Lyme disease: A retrospective analysis

Lyme-Borreliose und Lyme-Arthritis

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