Treatment of Epithelioid Sarcoma at the Royal Marsden Hospital

Livi, Lorenzo; Shah, Neelam G.; Paiar, Fabiola; Fisher, Cyril; Judson, Ian; Moskovic, E.; Thomas, Meirion; Harmer, C.

doi:10.1080/13577140310001644760

Cited by 37 publications

(40 citation statements)

References 22 publications

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“…Livi et al [27] studied 29 patients over a 23-year period and reported poor prognosis with axial location and increased depth of the primary lesion. This observation has been confirmed by others [7,8,39].…”

Section: Discussionmentioning

confidence: 99%

“…The small number of patients in many of the studies [3, 5-8, 11, 27, 36, 39, 44] limited their statistical power when identifying important prognostic factors affecting outcomes (Table 5). In a report from the Royal Marsden Hospital, Livi et al [27] retrospectively reviewed 39 patients from 1978 to 2001. Patient followup time was limited in most of the studies and the largest study to date did not report 5-and/or 10-year survival [8].…”

Section: Discussionmentioning

confidence: 99%

“…The largest series to date by Chase and Enzinger [8] in 1985 described 241 patients from multiple centers. Two other larger series came from the Royal Marsden Hospital and the Mayo Clinic [5,27]. Although the numbers of patients are larger in these series than in other reported series, they are limited in statistical power.…”

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

Prognostic Factors for Survival in Patients with Epithelioid Sarcoma: 441 Cases from the SEER Database

Jawad

Extein²,

Min

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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Current stratification of prognosis in patients with epithelioid sarcoma (ES) is based largely on data reported by individual centers with a limited number of patients. We sought to identify the important prognostic parameters using the Surveillance, Epidemiology, and End Results (SEER) database. We identified 441 patients with ES in the database and extracted information regarding patient demographics and clinical characteristics. KaplanMeier, log-rank, and Cox regression were used for analysis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic Factors for Survival in Patients with Epithelioid Sarcoma: 441 Cases from the SEER Database

Jawad

Extein²,

Min

et al. 2009

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

show abstract

“…Wide surgical excision, with clear resection margins remains the primary goal [1,14,20]. In a recent study, Livi et al [22] investigated the role of postoperative radiotherapy in 22 patients with ES. Thirty percent of the patients developed local recurrence and half of them developed metastases despite further surgery, subsequently dying of disease.…”

Section: Discussionmentioning

confidence: 99%

Proximal-Type Epithelioid Sarcoma in the Groin Presenting as a Diagnostic Dilemma

Mannan

Rifaat

Kahvic

et al. 2009

Pathol. Oncol. Res.

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Epithelioid sarcoma is an uncommon soft-tissue sarcoma typically presenting as a subcutaneous or deep dermal mass in the distal extremities of young adults. Lately, a 'proximal' subtype has been described, which occurs in the pelvic and genital areas of somewhat older individuals and tends to behave more aggressively than the conventional subtype. The correct diagnosis of this subtype is essential, since this tumor can be easily mistaken for other malignant tumors that exhibit epithelioid morphology. We report a case of proximal-type epithelioid sarcoma that presented as an inguinal mass in a 47-year-old man. Histologically, the tumor consisted of diffuse sheets of epithelioid cells with scattered rhabdoid morphology. By immunohistochemistry, the neoplastic cells expressed cytokeratin, epithelial membrane antigen, vimentin, CD34, CD99 and showed complete loss of nuclear INI1 protein expression. Fluorescence in situ hybridization was considered borderline for 22q deletion. We present this case to emphasize the importance of diagnosing this uncommon tumor and the role of INI1 immunohistochemistry in establishing the diagnosis.

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“…Epithelioid sarcoma is a rare malignant tumor with an incidence of 0.6-1.0% among sarcomas (8,9), and has an extremely poor prognosis. Metastases develop in 40-50% of patients, usually after repeated recurrences, and frequently involve the lung and regional lymph node (10).…”

Section: Discussionmentioning

confidence: 99%

An unusual presentation of pneumothorax associated with cystic lung metastasis from epithelioid sarcoma: A case report and review of the literature

et al. 2018

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Abstract. Circumscribed solid nodules are common in pulmonary metastases from sarcoma, but cystic pulmonary metastases from sarcomas are extremely rare. An unusual case of a 33-year-old man presenting with left spontaneous pneumothorax in association with cystic pulmonary metastases from an epithelioid sarcoma in the left forearm was discussed in the present study. The patient underwent wide resection of an epithelioid sarcoma in the left forearm 6 years prior. Periodical computed tomography revealed a gradual increase in the number and size of bilateral multiple cystic pulmonary metastases despite repeated chemotherapy treatment. At 33 years of age, the patient visited the outpatient department for sudden left chest pain and dyspnea. Plain radiography demonstrated spontaneous pneumothorax in the left lung; chest tube insertion and pleurodesis were successfully performed thereafter. At the last follow-up, 24 months after spontaneous pneumothorax, he is still alive and receiving chemotherapy treatment. Spontaneous pneumothorax is a common complication associated with cystic pulmonary metastases from epithelioid sarcoma. Orthopedic oncologists need to be aware of this unusual sarcomatous metastasis during the follow-up of advanced epithelioid sarcoma.

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Treatment of Epithelioid Sarcoma at the Royal Marsden Hospital

Cited by 37 publications

References 22 publications

Prognostic Factors for Survival in Patients with Epithelioid Sarcoma: 441 Cases from the SEER Database

Prognostic Factors for Survival in Patients with Epithelioid Sarcoma: 441 Cases from the SEER Database

Proximal-Type Epithelioid Sarcoma in the Groin Presenting as a Diagnostic Dilemma

An unusual presentation of pneumothorax associated with cystic lung metastasis from epithelioid sarcoma: A case report and review of the literature

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