Treatment of Eosinophilic Annular Erythema: Retrospective multicenter study and literature review

Vesiculobullous eosinophilic annular erythema: A case report

“…This may suggest that EAE patients with more extensive skin involvement and peripheral eosinophilia can be refractory to systemic prednisone as a monotherapy and may need other treatments like dapsone which has been described as a therapeutical option with good clinical response. 5 Other treatments described for classical EAE includes hydroxychloroquine, hydroxychloroquine combined with systemic corticosteroids, thalidomide, ultraviolet B (UVB) phototherapy, IL-5 inhibitor, dupilumab, or baricitinib. 5 EAE is a rare eosinophilic dermatosis that should be kept in mind in front of annular, arcuate cutaneous eruption.…”

Eosinophilic Annular Erythema: A New Entity of Eosinophilic Dermatosis

“…Thus, several hypotheses have been put forward in this sense, involving the role of IL-5 in the recruitment of eosinophils in response to certain stimuli such as insect bites. Another hypothesis concerns the presence of a receptor for IL-2 (CD25) on the surface of eosinophils, which causes or participates in their granulation [ 9 , 10 ]. Other published cases suggest the association of EAE with several chronic diseases such as autoimmune thyroid disease, diabetes mellitus, chronic borreliosis, autoimmune hepatitis, hepatitis C infection, hematological disorders, systemic lupus erythematosus, and rheumatoid arthritis, as well as chronic Helicobacter pylori gastritis, as in our patient [ 7 ].…”

“…Other published cases suggest the association of EAE with several chronic diseases such as autoimmune thyroid disease, diabetes mellitus, chronic borreliosis, autoimmune hepatitis, hepatitis C infection, hematological disorders, systemic lupus erythematosus, and rheumatoid arthritis, as well as chronic Helicobacter pylori gastritis, as in our patient [ 7 ]. Although suspected to be a hypersensitivity reaction, association with internal malignancy has been reported, including renal cell carcinoma, metastatic adenocarcinoma of the prostate, thymoma, which completely resolved after thymectomy, and breast cancer [ 7 , 10 ].…”

A case of annular erythema of infancy accompanied by elevated tryptase

“…The present case was most consistent with the eosinophilic variant. There is no standard treatment, but several options may be considered for the eosinophilic variant including topical and systemic steroids, antimalarials, dapsone, and monoclonal antibodies such as dupilumab 5,6 . In practice, AEI is really a diagnosis of exclusion given its relatively nonspecific clinical presentation and histopathology.…”

“…There is no standard treatment, but several options may be considered for the eosinophilic variant including topical and systemic steroids, antimalarials, dapsone, and monoclonal antibodies such as dupilumab. 5 , 6 In practice, AEI is really a diagnosis of exclusion given its relatively nonspecific clinical presentation and histopathology. Although benign, AEI must be differentiated from other conditions that may present with annular lesions during infancy, especially neonatal lupus erythematosus (Table 1 ).…”