Treatment of Enterococcal Peritonitis with Intraperitoneal Daptomycin in a Vancomycin-Allergic Patient and a review of the literature

Gilmore, James F.; Kim, Min Ji; LaSalvia, Mary T.; Mahoney, Monica V

doi:10.3747/pdi.2012.00277

Cited by 14 publications

(12 citation statements)

References 11 publications

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“…For vancomycin-resistant enterococcus (VRE) causing peritonitis, if the bacterial isolate is ampicillin-susceptible, ampicillin remains the drug of choice. Otherwise, linezolid, quinupristin/dalfopristin, or daptomycin are valid options ( 278 , 281 , 292 , 360 – 363 ). Given the clinical efficacy and profile of adverse effects, daptomycin is probably the first-line antibiotic of choice for peritonitis episodes caused by VRE ( 278 , 363 – 365 ).…”

Section: Subsequent Management Of Peritonitismentioning

confidence: 99%

ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment

et al. 2016

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Section: Subsequent Management Of Peritonitismentioning

confidence: 99%

ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment

et al. 2016

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“…2 The most frequently reported daptomycin-dosing regimen has been a loading dose of 100 mg/L intraperitoneally, followed by 20 mg/L intraperitoneally for subsequent doses. 34,35 Daptomycin has also been used successfully in a patient on automated perineal dialysis given 7 mg/kg intraperitoneally every 48 hours 22 and in a patient given 5 mg/kg IV every 48 hours. 21 Another simpler regimen is 200 mg intraperitoneally during the long dwell in patients on automated PD.…”

Section: Streptococcal Peritonitismentioning

confidence: 99%

Peritoneal dialysis-related peritonitis: challenges and solutions

Salzer

2018

IJNRD

106

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Peritoneal dialysis is an effective treatment modality for patients with end-stage renal disease. The relative use of peritoneal dialysis versus hemodialysis varies widely by country. Data from a 2004 survey reports the percentage of patients with end-stage renal disease treated with peritoneal dialysis to be 5%–10% in economically developed regions like the US and Western Europe to as much as 75% in Mexico. This disparity is probably related to the availability and access to hemodialysis, or in some cases patient preference for peritoneal over hemodialysis. Peritoneal dialysis-related peritonitis remains the major complication and primary challenge to the long-term success of peritoneal dialysis. Fifty years ago, with the advent of the Tenckhoff catheter, patients averaged six episodes of peritonitis per year on peritoneal dialysis. In 2016, the International Society for Peritoneal Dialysis proposed a benchmark of 0.5 episodes of peritonitis per year or one episode every 2 years. Despite the marked reduction in peritonitis over time, peritonitis for the individual patient is problematic. The mortality for an episode of peritonitis is 5% and is a cofactor for mortality in another 16% of affected patients. Prevention of peritonitis and prompt and appropriate management of peritonitis is essential for the long-term success of peritoneal dialysis in all patients. In this review, challenges and solutions are addressed regarding the pathogenesis, clinical features, diagnosis, treatment, and prevention of peritoneal dialysis-related peritonitis from the viewpoint of an infectious disease physician.

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“…Однако также наблюдается реакция крови со стороны базофилов. Можно предположить, что значительное снижение количества базофилов определяется наличием аллергического компонента при РГП и, соответственно, их миграцией в зону воспаления [15,25,33].…”

Section: Discussionunclassified

Regulatory Influence of Blood Monocytes on the Population Composition of Granulocytes and the State of Their Respiratory Burst in the Widespread Purulent Peritonitis

Савченко¹,

Борисов²,

Черданцев³

et al. 2018

Russian Journal of Infection and Immunity

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The aim of the study was to investigate the regulatory effect of monocytes and their subpopulations on the population composition of granulocyte leukocytes and the state of their respiratory burst in widespread purulent peritonitis (WPP). The study involved 24 patients aged 30-65 with acute surgical diseases and injuries of abdominal organs complicated by WPP. As a control 25 relatively healthy people of the same age range were examined. A study of the population composition of monocytes and granulocyte leukocytes in blood was performed using a two-platform technology on the hematological analyzer Sysmex XE-5000 (Sysmex Inc., USA) and FC-500 flow cytometer (Beckman Coulter, USA) using the Cytodiff antibody kit (Beckman Coulter, USA). A study of the monocytes number expressing HLA-DR- and CD64-receptor was performed by flow cytometry using direct immunofluorescence of whole peripheral blood. The respiratory burst state of neutrophilic granulocytes was studied by chemiluminescence analysis on a 36-channel chemiluminescence analyzer BLM-3607 (MedBioTech, Russia). As indicators of chemiluminescence were used luminol and lucigenin. The enhancement of chemiluminescence induced by zymosan was evaluated by the ratio of the area of the induced chemiluminescence to the spontaneous area and was defined as the activation index. It has been established that the immune-inflammatory process in WPP is characterized by a decrease in the number of classical monocytes in the peripheral blood and an increase in the content of non-classical monocytes. In WPP in peripheral blood the level of monocytes expressing HLA-DR receptors decreases. The change in the ratio of monocytes subpopulations characterizes the increase in the role of the proinflammatory fraction in the WPP pathogenesis. Changes in the population composition of granulocytes in the blood in patients with WPP also characterize the development of an acute inflammatory process. In this case, there is a decrease in the number of basophils in the peripheral blood, which, apparently, is determined by the presence of an allergic component in WPP and, accordingly, their migration to the inflammation area. In patients with WPP activation of a respiratory burst of granulocytes of blood was detected, the intensity of which is determined by the synthesis of primary and secondary active oxygen species. The results of the correlation analysis made it possible to establish that in WPP the regulatory role of non-classical monocytes increases aimed at stimulating the inflammatory processes (an increase in the number of mature and immature forms of neutrophils and stimulation of the activity of a respiratory explosion of granulocytes). The revealed features of the regulatory effect of monocytes on the population composition and the intensity of the respiratory burst of granulocytes can be used in the development of immunotherapeutic methods aimed at reducing the activity of the inflammatory process in WPP.

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Treatment of Enterococcal Peritonitis with Intraperitoneal Daptomycin in a Vancomycin-Allergic Patient and a review of the literature

Cited by 14 publications

References 11 publications

ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment

ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment

Peritoneal dialysis-related peritonitis: challenges and solutions

Regulatory Influence of Blood Monocytes on the Population Composition of Granulocytes and the State of Their Respiratory Burst in the Widespread Purulent Peritonitis

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