Treatment of endobronchial metastases with intraluminal radiotherapy

Quantrill, Simon; Burt, Paul A; Barber, Philip; Stout, Ronald

doi:10.1053/rmed.1999.0731

Cited by 20 publications

(4 citation statements)

References 23 publications

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“…Intraluminal radiotherapy is one of the treatment choices for the palliation of symptoms [21][22][23]. However, its effect on survival time has not yet been fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Metastases from Extrathoracic Malignancies

Akoglu

Uçan

Çelik

et al. 2005

Clin Exp Metastasis

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Endobronchial metastases (EBM) from extrapulmonary malignant tumors are rare. The most common extrathoracic malignancies associated with EBM are breast, renal and colorectal carcinomas. In this study, we aimed to evaluate the clinical, radiographic and bronchoscopic aspects of patients with EBM who were diagnosed between 1992 and 2002. Data about patients' clinical conditions, symptoms, radiographic and endoscopic findings, and histopathological examination results were investigated. EBM was defined as bronchoscopically visible lesions histopathologically identical to the primary tumor in patients with extrapulmonary malignancies. We found 15 cases with EBM. Primary tumors included breast (3), colorectal (3), and renal (2) carcinomas; Malignant Melanoma (2); synovial sarcoma (1), ampulla of Vater adenocarcinoma (1), pheochromocytoma (1), hypernephroma (1), and Hodgkin's Disease (1). The most common symptoms were dyspnea (80%), cough (66.6%) and hemoptysis (33.3%). Multiple (40%) or single (13.3%) pulmonary nodules, mediastinal or hilar lymphadenopathy (40%), and effusion (40%) were the most common radiographic findings. The mean interval from initial diagnosis to diagnosis of EBM was 32.8 months (range, 0-96 months) and median survival time was 18 months (range, 4-84). As a conclusion, various extrapulmonary tumors can metastasize to the bronchus. Symptoms and radiographic findings are similar with those in primary lung cancer. Therefore, EBM should be discriminated from primary lung cancer histopathologically. Although mean survival time is usually short, long-term survivors were reported. Consequently, treatment must be planned according to the histology of the primary tumor, evidence of metastasis to other sites and medical status of the patient.

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“…Intraluminal radiotherapy is one of the treatment choices for the palliation of symptoms [21][22][23]. However, its effect on survival time has not yet been fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Metastases from Extrathoracic Malignancies

Akoglu

Uçan

Çelik

et al. 2005

Clin Exp Metastasis

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“…Sørensen et al found that around two-thirds of patients benefited symptomatically from ILT 10. This offers a distinct advantage over external beam therapy as it can deliver high-dose radiation to a localised area with significantly less side effects, especially when the patient already has a decreased cardiac or pulmonary functional status 11…”

Section: Discussionmentioning

confidence: 99%

Endobronchial metastasis as an uncommon pattern of metastatic dissemination from small cell osteosarcoma

Syriac¹,

Bhaskarla

Elrifai

et al. 2019

BMJ Case Rep

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Endobronchial metastasis (EBM) from extrapulmonary primary malignancy is a rare entity. Although the most common site of metastasis of osteosarcoma is the lungs, EBM remains a rare occurrence. Cough and dyspnea are the most common symptoms. A significant number of patients are asymptomatic, making the diagnosis without any radiographic imaging challenging. CT scan of the lung, along with bronchoscopy and biopsy, is the mainstay of diagnosis and staging. A 36-year-old man presented with small cell osteosarcoma of the left maxillary region and was treated with surgery and adjuvant chemotherapy. The patient presented 8 years later with axillary metastasis and was found to have lung metastasis on further workup. Bronchoscopy and biopsy proved an EBM that was debulked by hot snare technique. The patient was then started on chemotherapy for recurrent small cell osteosarcoma.

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“…The presence of endobronchial metastases usually implies a poor prognosis. 9 Endobronchial metastases in FTC can develop via several mechanisms. It has been hypothesized that bronchial lesions can occur due to direct invasion of parenchymal lesion, direct extension of mediastinal lesions, transbronchial aspiration, direct lymphatic spread, and/or direct metastasis via the bronchial artery.…”

Section: Discussionmentioning

confidence: 99%

Follicular Thyroid Carcinoma Presenting With Endobronchial Metastases

Onyeaso

Gosmanov

2014

Journal of Investigative Medicine High Impact Case Reports

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Endobronchial metastasis is a rare manifestation of differentiated thyroid cancer. A 79-year-old male was admitted to the hospital with shortness of breath, chest pain, anemia, and weight loss. Computed tomography of chest revealed multiple lung nodules. Bronchoscopy showed an endobronchial lesion in the right upper lobe. The biopsy of the lesion demonstrated neoplastic cells stained positive for thyroglobulin, thyroid transcription factor-1, and cytokeratin-7, consistent with metastatic follicular thyroid cancer. Physical examination revealed a firm fixed thyroid nodule, which was confirmed by thyroid ultrasound. He subsequently underwent total thyroidectomy and neck exploration. Thyroid gland pathology revealed a nodule with features of high-grade follicular thyroid carcinoma. Metastatic thyroid cancer should be considered in workup of pulmonary nodules. We recommend an examination of thyroid gland in patients who present with pulmonary nodules associated with signs and symptoms of malignancy.

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Treatment of endobronchial metastases with intraluminal radiotherapy

Cited by 20 publications

References 23 publications

Endobronchial Metastases from Extrathoracic Malignancies

Endobronchial Metastases from Extrathoracic Malignancies

Endobronchial metastasis as an uncommon pattern of metastatic dissemination from small cell osteosarcoma

Follicular Thyroid Carcinoma Presenting With Endobronchial Metastases

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