Treatment of Elevated Intracranial Pressure With Dimethyl Sulfoxide

Waller, Frederick T.; Tanabe, Calvin T.; Paxton, Harold D.

doi:10.1111/j.1749-6632.1983.tb47310.x

Cited by 36 publications

(12 citation statements)

References 16 publications

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“…DMSO successfully reduced traumatic intracranial hypertension resistent to mannitol, hyperventilation, and barbiturate coma. 8 In experimental brain injury* 710 " and in head injury patients at our institution (unpublished data) and elsewhere, 89 DMSO has lowered ICP, sometimes within minutes. The mechanism by which DMSO lowers ICP is unknown, but the rapid onset of action raises the possibility of direct cerebral vasoconstriction and consequent reduction in intracranial volume and pressure.…”

Section: Discussionmentioning

confidence: 89%

Vasomotor effects of dimethyl sulfoxide on cat cerebral arteries in vitro and in vivo.

Pitts¹,

Young²,

McCulloch³

et al. 1986

Stroke

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SUMMARY We studied the direct vascular effects of dimethyl sulfoxide (DMSO) in isolated middle cerebral arteries and on pial arteriolar caliber after subarachnoid perivascular microinjection in chloralose-anesthetized cats, and on brain retraction in cats given DMSO intravenously. DMSO did not constrict isolated cerebral arteries at any of the concentrations studied (10~'° to 4 x 10~' M). In middle cerebral arteries precontracted with potassium, 5-hydroxytryptamlne, prostagiandin F 2 alflha , or with mechanically raised tone, DMSO at concentrations of 10" l0 to 10~2 M had no significant effects; at concentrations greater than 10 ~2 M, DMSO consistently relaxed the arteries, probably because of the hyperosmolarity of the bathing solution. Mkroapplication of DMSO (10~6 to 10" 3 M) around pial arterioles on the cortical surface did not change arteriolar caliber signlikantly. Higher concentrations of DMSO (1%) increased arteriolar caliber by 56 ± 4% (p < 0.001), probably as a consequence of solution hypertonicity. DMSO did not modify In vivo cerebrovascular responses to alterations in perivascular potassium ion concentrations. Intravenous administration of DMSO did cause obvious brain shrinkage. These data provide no support for the view that direct cerebral vascular effects play a major role in the clinical efficacy of DMSO, but are consistent with the hypothesis that DMSO's ability to lower intracraniai pressure derives from its osmotic effect on cerebral issue.

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Section: Discussionmentioning

confidence: 89%

Vasomotor effects of dimethyl sulfoxide on cat cerebral arteries in vitro and in vivo.

Pitts¹,

Young²,

McCulloch³

et al. 1986

Stroke

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“…While transient hemoglobinuria occurred when the DMSO concentration was high (cases 6 and 7), studies show that this causes no renal damage [13]. Concentration of DMSO in these cases was 20-40%.…”

Section: Discussionmentioning

confidence: 98%

Dimethylsulfoxide (DMSO) for human single-stage intraoperative tissue expansion and circulatory enhancement

Vinnik

Jacob

1991

Aesth. Plast. Surg.

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Dimethylsulfoxide (DMSO) has been in clinical use since the early 1960s. In 1967 the discovery that DMSO can greatly reduce ischemia in experimental pedicle flaps stimulated its use in plastic surgery by the authors since 1976. In 1987 its ability to soften collagen, thus permitting degrees of immediate intraoperative tissue expansion hitherto unknown, was applied clinically for the first time. Evolving use of topical 70% DMSO alone, in combination with intravenous DMSO, and intravenous DMSO alone with greater efficacy is discussed. Cases of intraoperative tissue expansion for large lesion excision and use in abdominoplasty to maximize skin resection are discussed. In breast reconstruction, maximal tissue expansion in minutes with immediate placement of large permanent prostheses ends the delay of reconstruction and problems of chronic tissue expander capsule formation and gives this technique a clear advantage over other reconstructive techniques.

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“…The cortical cytoprotective effect seen after dimethyl sulfoxide treatment may result from the ability by this compound to increase CBF in pathologic brain ischemia ( Dimethyl sulfoxide has been found useful against a variety of CNS trauma in animals (de la Torre 1983) and preliminary clinicd trials using this compound in cerebral injury appear encouraging (Mullan et d. 1880;Marshall et d-1984;Gumerlwk and Neuwelt 1984;Waller et al 1983). We have recently reported the reduction of intracranid hypertension following close-head injury in 10 patients given intravenous DS for as long as 10 days (Karaca et d-1990).…”

Section: Ce~*ebr~and Blood Flow Examiaatisnmentioning

confidence: 99%

Synergic activity of combined prostacyclin: dimethyl sulfoxide in experimental brain ischemia

Torre¹

1991

Can. J. Physiol. Pharmacol.

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DE LA TORWE, 9. C. 1991. Synergic activity of combined prostacyclin: dimethyl sulfoxide in exprirnental brain ischemia.Can. J. Physiol. Phmacol. 69: 191 -138. We examined whether dmgs that blmk calcium, prostaglandins, free radicals, and endorphin release could modify cerebral blood flow or nerve tissue pathology following a focal cerebrovascular lesion. Cats were randomly divided into six groups and were subjected to standard middle cerebrd artery occlusion (MCAO) performed using a transorbital approach. One hour after MCAO, cats received the following cornpounds intravenously: (i) d i n e (CS), 1.5 mL/kg or polyethylene glycol, 300 pg (CP); (ii) waloxsne (NX), 2 mg/kg; (iii) n i d i p i n e (NM), 1 pg . kg-' min-' x 660 min; (iv) dimethyl sulfoxide (DS), 0.9 g6kg in a 48% solution; (v) prostacyclin (PGH,), 200 ng . kg-'min-' for 60 min; or (vh) DS-PGI, combined.At 1-h intervals, Imal CBF was recorded from the cortical tissue proximal and distal to the MCAO site using the hydrogen clearance method. Five hours after MCAO, cortical tissue was removed for catecholamine histofluorescence or perfaased for tyrosine hydroxylase immunoreactive axon examination. Treatment with NX, NM, CP, or CS had no effect on either CBF or co~ticrpl tissue neurotransmitter morphology. BGI, showed a transiently modest but significant increase of CBF, while DS provided moderate protection of catecholiaminergic fibers and increased CBF by 27% after MCAO. The combination of DS -X I , resulted in significant cytoprotection of cortical catecholaminergic fibers and generated a sustained CBF increase of 68% of control values. These findings suggest that combining DS with PG12 can yield a synergic effect with respect to cortical neurotransmitter and CBF protection after MCAO. DE LA TORRE, J. C. 1991. Synergic activity sf combined prostacyclin: dimethyl sulfoxide in experimental brain ischemia. Can. 3. Physiol. Phamacol. 69 : 191 -198. Nous awns examine si les drogues qui bloquent la IibCration d'endorphine, de radicaux libres, de prostaglandines et de calcium pouvaient modifier le debit sanguin cCr6bral ou le tissu nerveux aprks une 1Csion cer6brovasculaire focale. Des chats ont kt6 repartis au hasard en six groupes et soumis B une occlusion de 19art&re ckrkbrale moyenne (OACM) en utilisant une approche transorbitaire. &me heure aprks l'BACM, les chats ont reCu les perfusions intraveineuse suivantes : (i) solution saline (CS) 1,5 d / k g ou poly6thylkne glycol, 300 pg (CP); (ii) naloxone (NX) 2 mg6kg; (iii) nimdipine (NM) 1 hgkg-' . m i n -b 60 min; (iv) dimethyl-sulfoxide (DS) 0,9 g/kg en solution de 40% ' Q; (v) prostacycline (PGH,) 200 ng kg-I * min-I pendant 60 min ou (vi) DS -PGI, combines. Le dbbit sanguin cerebral local du tissu cortical proximal et dista% B1'OACM a 6t6 enregistrd B intemalles d' 1 h, en utilisant la m6kode de clairance de 19hydrog&ne. Cinq heures apr&s Z'BACM, du tissu cortical a 6tC soit prelev6 pour l'histoflusrescence des cat6cholamines, soit perfus6 pour 17examen de la tyrosine hydroxylase axomle imunorCactive. Le t...

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Treatment of Elevated Intracranial Pressure With Dimethyl Sulfoxide

Cited by 36 publications

References 16 publications

Vasomotor effects of dimethyl sulfoxide on cat cerebral arteries in vitro and in vivo.

Vasomotor effects of dimethyl sulfoxide on cat cerebral arteries in vitro and in vivo.

Dimethylsulfoxide (DMSO) for human single-stage intraoperative tissue expansion and circulatory enhancement

Synergic activity of combined prostacyclin: dimethyl sulfoxide in experimental brain ischemia

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