Treatment of diseases of the eye with mucoadhesive delivery systems

Greaves, Jane; Wilson, Clive G.

doi:10.1016/0169-409x(93)90016-w

Cited by 120 publications

(50 citation statements)

References 43 publications

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“…Prime targets have been the gastrointestinal tract and also the ocular surface to (1) retard the natural clearing action of the body, slowing down the transit through the optimal sites of absorption in the stomach, intestine and colon [7] and (2) slow down the washing away action on the surface of the eye [8], respectively. In order to develop the most efficient systems, a sensible approach is to take advantage of the considerable advances in our knowledge of the structure and molecular Abbreviations used : AFM, atomic force microscopy ; PGM, pig gastric mucin ; APTES, aminopropyl-triethoxysilane ; RMS, root-mean-square ; SC210j, sea cure j210 ; z, vertical displacement.…”

Section: Introductionmentioning

confidence: 99%

Atomic force microscopy of gastric mucin and chitosan mucoadhesive systems

Deacon

McGurk

Roberts

et al. 2000

Biochemical Journal

117

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Atomic force microscopy has been utilized to probe, at a molecular level, the interaction between purified pig gastric mucin (PGM) and a mucoadhesive cationic polymer, chitosan (sea cure 210j), with a low degree (approx. 11 %) of acetylation. Images were produced detailing the structures of both PGM and chitosan in 0.1 M acetate buffer (pH 4.5), followed by the complex of the two structures in the same buffer. PGM in 0.1 M acetate buffer revealed long linear filamentous structures, consistent with earlier electron microscopy and scanning tunnelling micoscopy studies. The chitosan molecules also adopted a linear conformation in the same buffer, although with a smaller average

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Section: Introductionmentioning

confidence: 99%

Atomic force microscopy of gastric mucin and chitosan mucoadhesive systems

Deacon

McGurk

Roberts

et al. 2000

Biochemical Journal

117

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“…This viscosity was also compared with that of a CS solution incubated in the same conditions. This kind of measurement is important because the blink process requires a low tear viscosity in order to avoid damage to the corneal epithelium (10). Therefore, a significant increase in this parameter should, preferably, be avoided.…”

Section: Stability Of Cs-fl Nanoparticles In the Presence Of Mucus Comentioning

confidence: 99%

“…Another strategy aimed to increase the residence time of drugs in the precorneal area has been the use of mucoadhesive polymers (10,11). Among them, the cationic polysaccharide chitosan (CS) exhibits several favorable biological properties, such as biodegradability (12), nontoxicity (13), biocompatibility (14), and mucoadhesiveness.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Nanoparticles as New Ocular Drug Delivery Systems: in Vitro Stability, in Vivo Fate, and Cellular Toxicity

et al. 2004

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Purpose. To assess the potential of chitosan (CS) nanoparticles for ocular drug delivery by investigating their interaction with the ocular mucosa in vivo and also their toxicity in conjunctival cell cultures. Methods. Fluorescent (CS-fl) nanoparticles were prepared by ionotropic gelation. The stability of the particles in the presence of lysozyme was investigated by determining the size and their interaction with mucin, by measuring the viscosity of the mucin dispersion. The in vivo interaction of CS-fl nanoparticles with the rabbit cornea and conjunctiva was analyzed by spectrofluorimetry and confocal microscopy. Their potential toxicity was assessed in a human conjunctival cell line by determining cell survival and viability. Results. CS-fl nanoparticles were stable upon incubation with lysozyme and did not affect the viscosity of a mucin dispersion. In vivo studies showed that the amounts of CS-fl in cornea and conjunctiva were significantly higher for CS-fl nanoparticles than for a control CS-fl solution, these amounts being fairly constant for up to 24 h. Confocal studies suggest that nanoparticles penetrate into the corneal and conjunctival epithelia. Cell survival at 24 h after incubation with CS nanoparticles was high and the viability of the recovered cells was near 100%. Conclusions. CS nanoparticles are promising vehicles for ocular drug delivery.

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“…Within this research context, it is currently accepted that the primary objectives indicated above (prolonged retention, enhanced penetration and controlled delivery) can be attained though different strategies that include the use of bioadhesive polymers, penetration enhancers and the advanced design of micro-and nanoparticulate delivery systems. These approaches have been explored independently over the last decade (Greaves & Wilson 1993;Kaur & Smitha 2002) and have led to significant advances in the field. Probably, an adequate combination of them will lead to a new generation of ocular drug delivery systems.…”

Section: Barriers To Overcome In Topical Ocular Drug Deliverymentioning

confidence: 99%

The potential of chitosan in ocular drug delivery

Alonso

Sánchez

2003

Journal of Pharmacy and Pharmacology

305

123

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This paper presents an overview of the potential of chitosan-based systems for improving the retention and biodistribution of drugs applied topically onto the eye. Besides its low toxicity and good ocular tolerance, chitosan exhibits favourable biological behaviour, such as bioadhesion-and permeability-enhancing properties, and also interesting physico-chemical characteristics, which make it a unique material for the design of ocular drug delivery vehicles. The review summarizes the techniques for the production of chitosan gels, chitosan-coated colloidal systems and chitosan nanoparticles, and describes their mechanism of action upon contact with the ocular mucosa. The results reported until now have provided evidence of the potential of chitosan gels for enhancing and prolonging the retention of drugs on the eye surface. On the other hand, chitosan-based colloidal systems were found to work as transmucosal drug carriers, either facilitating the transport of drugs to the inner eye (chitosan-coated colloidal systems containing indometacin) or their accumulation into the corneal/conjunctival epithelia (chitosan nanoparticles containing ciclosporin). Finally, the tolerance, toxicity and biodegradation of the carriers under evaluation were reviewed.

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Treatment of diseases of the eye with mucoadhesive delivery systems

Cited by 120 publications

References 43 publications

Atomic force microscopy of gastric mucin and chitosan mucoadhesive systems

Atomic force microscopy of gastric mucin and chitosan mucoadhesive systems

Chitosan Nanoparticles as New Ocular Drug Delivery Systems: in Vitro Stability, in Vivo Fate, and Cellular Toxicity

The potential of chitosan in ocular drug delivery

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