Treatment of dental and orthodontic complications in thalassaemia

Mulimani, Priti; Abas, Adinegara BL; Karanth, Laxminarayan; Colombatti, Raffaella; Kulkarni, Palna

doi:10.1002/14651858.cd012969

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…Nevertheless, the lack of early of orthodontic treatment leads to the development of severe facial deformities, which will require treatment later by means of orthognathic surgery. 20 But the present study concluded that there is generalized growth retardation/delayed puberty in thalassemic patients leading to diminished mandibular growth, rather than maxillary prognathism thus the orthosurgical treatement should be planned accordingly. The role of functional appliances and orthopedic appliances to enhance the growth during pubertal growth spurt should not be ignored that may improve the esthetics of patients decreasing the requirement of more complicated surgeries.…”

Section: Discussionmentioning

confidence: 57%

“…Probably, a complete diagnostic and therapeutic hematologic strategy is not easy to apply on a large-scale basis, especially in developing countries of limited health resources or in countries where abortions are banned. Nevertheless, the lack of early of orthodontic treatment leads to the development of severe facial deformities, which will require treatment later by means of orthognathic surgery 20…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Quantitative Aspects of Craniofacial Deformities in Transfusion Dependent Beta-Thalassemia Major Patients: A Cephalometric Study

Gupta

Singh

Utreja

et al. 2022

Journal of Craniofacial Surgery

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Purpose: To evaluate the quantitative (cephalometric) aspects of the craniofacial deformities in transfusion-dependent beta-thalassemia (TDT) patients. Materials and Methods: Sixty-five TDT patients receiving a regular blood transfusion in the Department of Pediatrics of age group 5 to 8 years (younger) and 15 years and above (older) were compared with control groups of similar age using cephalograms (lateral and posterior-anterior view). Results and Observation: The prevalence of skeletal class II tendency is higher in thalassemic patients that do not improve with age. The thalassemic patients were found to show large angle ANB i.e. Angle between points point a, nasion and point B (ANB), large flexure angle, small angle SNB i.e. Angle between points sella, nasion and point B (SNB), and normal angle SNA i.e. Angle between points sella, nasion and point A (SNA) angles suggestive of retrognathic mandible. The thalassemic patients were observed to have smaller transverse widths and thickened calvarium on the posterior-anterior view. Conclusion:The skeletal class II malocclusion appears to be a manifestation of generalized growth retardation/delayed puberty in thalassemic patients leading to diminished mandibular growth, rather than maxillary prognathism due to marrow hyperplasia.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Evaluation of Quantitative Aspects of Craniofacial Deformities in Transfusion Dependent Beta-Thalassemia Major Patients: A Cephalometric Study

Gupta

Singh

Utreja

et al. 2022

Journal of Craniofacial Surgery

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“…Initial observational studies of the craniofacial complex of thalassaemia patients have shown that they are more prone to a Class II skeletal pattern (increased facial convexity with the mandible positioned posteriorly www.nature.com/scientificreports/ at the sagittal level in relation to the maxilla), without being able to define the exact structural differences from the normal population that could support their findings 10,11 . Further observational anthropometric studies are available 14,[32][33][34][35][36] , while 6 more studies [15][16][17][37][38][39] and one systematic review 40 could be found in the literature. These studies used conventional cephalometrics to compare beta thalassaemia patients with controls.…”

Section: Discussionmentioning

confidence: 99%

Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis

Ρούσσος

Mitsea

Halazonetis

et al. 2021

Sci Rep

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The shape of the craniofacial complex of patients with beta thalassaemia was evaluated using geometric morphometrics on lateral cephalometric radiographs and was compared with matched controls. The beta thalassaemia group consisted of 40 patients (16 females, 24 males, mean age 33.4). Each patient was matched by age and gender to two controls (32 females, 48 males, mean age 33.1). The 120 lateral cephalometric radiographs were digitized and traced with 15 curves, 10 landmarks and 117 sliding semi-landmarks. These landmarks were subjected to Procrustes superimposition and principal component analysis in order to describe shape variability of the cranial base, maxilla and mandible, as well as of the entire craniofacial complex for each sex. The first 4 principal components accounted for 50% of the total sample’s variability. The beta thalassaemia group was significantly different in overall shape to the control group for both sexes. Similar findings were noted for the maxilla, the mandible and the cranial base. The main differences were related to smaller mandibular body for the thalassaemia group, midface protrusion and decrease in posterior face height. The shape of the craniofacial complex in these patients is prone to be more convex and hyperdivergent.

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