Treatment of demodicosis in dogs: 2011 clinical practice guidelines

Mueller, Ralf S.; Bensignor, Emmanuel; Ferrer, L.; Holm, Birgit R.; Lemarie, Stephen L.; Paradis, Manon; Shipstone, Michael A.

doi:10.1111/j.1365-3164.2011.01026.x

Cited by 98 publications

(207 citation statements)

References 52 publications

(123 reference statements)

Supporting

Mentioning

169

Contrasting

Unclassified

Order By: Relevance

“…In other cases, the dogs may present clinically normal results after treatment, but still demonstrate mites in skin scraping tests (Mueller et al 2012). Thus, studies evaluating therapeutic protocols against demodicosis should not use observation of the presence or absence of Demodex mites solely, or clinical appearance alone.…”

Section: Discussionmentioning

confidence: 99%

“…In recent decades, ivermectin has been extensively evaluated for treating canine demodicosis in various protocols, especially orally, and it is one of the most widely used drugs in the world (Mueller et al 2012). Efficacy of up to 89.7% has been reported when administered orally every day, but with treatment protocols of duration of up to 150 days (Ristic et al 1995, Delayte et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…All the animals were monthly monitored for twelve months following the withdrawal of the treatment protocols, which is the time period suggested in the literature for monitoring recurrence of clinical disease in dogs (Gortel 2006, Mueller et al 2012.…”

Section: Methodsmentioning

confidence: 99%

“…The different stages of D. canis were identified, counted and compared on each evaluation day, as recommended by Mueller et al (2012).…”

Section: Methodsmentioning

confidence: 99%

“…Another negative point is that some protocols are not very practicable, which decreases the pet owners' compliance. For this reason, it is necessary to search for alternative therapies, due to the possibility of failure or impracticality of the currently recommended treatments (Mueller et al 2012).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Clinical and parasitological evaluation of pour-on fluazuron and ivermectin for treating canine demodicosis

2014

View full text Add to dashboard Cite

RESUMO.-[Avaliação clínica e parasitológica do fluazuron e da ivermectina pour-on no tratamento da demodiciose canina.] O objetivo do presente estudo foi avaliar a eficácia do fluazuron e da ivermectina pour-on em diferentes protocolos terapêuticos no tratamento da demodiciose, através da quantificação de ácaros por raspados cutâneos e exames histológicos, além da avaliação dos cães. Foram avaliados 18 cães com raspados cutâneos positivos para o ácaro Demodex canis, divididos em três grupos. Todos os animais foram tratados a cada 14 dias, totalizando seis tratamentos em cada cão (Dias 0, 14, 28, 42, 56 e 70). No grupo 1 foi utilizado fluazuron 2,5% pour-on na dosagem de 20mg/kg; no grupo 2 foi empregado fluazuron 2,5% pour--on na dosagem de 20mg/kg associado a ivermectina 0,5% pour-on, na dosagem de 0,6mg/kg e, no grupo 3, somente ivermectina 0,5% pour-on 0,6mg/kg. The objective of the study was to evaluate the efficacy of pour-on formulations of fluazuron and ivermectin in different therapeutic protocols for treatment of demodicosis by means of quantifying mites with skin scraping, histological and clinical evaluation in dogs. Eighteen dogs with skin scrapings positive for Demodex canis were evaluated, divided into three groups. All the animals were treated every 14 days, completing 6 treatments for each animal (days 0, 14, 28, 42, 56 and 70). In group 1, pour-on 2.5% fluazuron was used at the dose of 20mg/kg; in the group 2 pour-on 2.5% fluazuron at a dose of 20 mg/kg in association with pour-on 0.5% ivermectin at the dose of 0.6mg/kg; and in group 3, pour-on 0.5% ivermectin alone was used, at the dose of 0.6mg/kg. The treatment was evaluated and monitored through skin scrapings and clinical follow-up of the lesions every 14 days for 84 days, and through histopathological examination at the end of each treatment protocol. The success rate was defined as the percentage of dogs in each group that had negative skin scrapings after the treatment: this was 16.67% for group 1, and 50% for groups 2 and 3. The reduction in mite counts reached effectiveness of 67.66%, 88.99% and 84.29% for groups 1, 2 and 3 respectively. The Wilcoxon test showed that there was a significant difference between the number of mites before and after treatment in groups 2 and 3. The histopathological examination revealed that only group 1 showed no significant difference in the intensity of infestation between days 0 and 84. Clinically, there was no significant difference between the evaluation before and after treatment in the three groups. Pour-on 2.5% fluazuron and pour-on 0.5% ivermectin were not effective for treating canine demodicosis, either in association or as single therapy, when applied every 14 days for a period of 70 days. Quantification of mites using skin scrapings and histological evaluation proved to be ineffective, either one as sole therapeutic evaluation parameters, for canine demodicosis.INDEX TERMS: Demodex canis, control, fluazuron, ivermectin, pour-on. 1095 Clinical and parasitological evaluation of pour-on fluazuro...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The different stages of D. canis were identified, counted and compared on each evaluation day, as recommended by Mueller et al (2012).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%