Treatment of cutaneous T-cell lymphoma (CTCL) by extracorporeal photochemotherapy

Nagatani, Tetsuya; Matsuzaki, Toshiko; Kim, Shutaku; Baba, Naoko; Ichiyama, Satoshi; Miyamoto, Hideaki; Nakajima, Hiroshi

doi:10.1016/0923-1811(90)90169-e

Cited by 2 publications

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“…Psoralen and its derivatives like 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP) increase cytotoxicity after UV irradiation with a wavelength of 320-400 nm and are effective against cutaneous T-cell lymphoma [154,155].…”

Section: Alkaloidsmentioning

confidence: 99%

Some Natural Photosensitizers and Their Medicinal Properties for Use in Photodynamic Therapy

et al. 2022

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Despite significant advances in early diagnosis and treatment, cancer is one of the leading causes of death. Photodynamic therapy (PDT) is a therapy for the treatment of many diseases, including cancer. This therapy uses a combination of a photosensitizer (PS), light irradiation of appropriate length and molecular oxygen. The photodynamic effect kills cancer cells through apoptosis, necrosis, or autophagy of tumor cells. PDT is a promising approach for eliminating various cancers but is not yet as widely applied in therapy as conventional chemotherapy. Currently, natural compounds with photosensitizing properties are being discovered and identified. A reduced toxicity to healthy tissues and a lower incidence of side effects inspires scientists to seek natural PS for PDT. In this review, several groups of compounds with photoactive properties are presented. The use of natural products has been shown to be a fruitful approach in the discovery of novel pharmaceuticals. This review focused on the anticancer activity of furanocoumarins, polyacetylenes, thiophenes, tolyporphins, curcumins, alkaloid and anthraquinones in relation to the light-absorbing properties. Attention will be paid to their phototoxic and anti-cancer effects on various types of cancer.

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Section: Alkaloidsmentioning

confidence: 99%

Some Natural Photosensitizers and Their Medicinal Properties for Use in Photodynamic Therapy

et al. 2022

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“…The enhanced activity against the malignant melanoma cell line (A375) after UV irradiation of plant extracts containing FC also supported the possible photoactive nature of FCs [ 93 , 94 , 95 , 96 ]. The linear forms of furanocoumarins like psoralen and its derivatives 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP) are reported to increase the cytotoxicity after irradiation by ultraviolet light in the 320–400 nm wavelength range against cutaneous T-cell lymphoma [ 97 , 98 ], and photoactivated psoralens induce apoptosis by forming adducts with DNA. This leads to the activation of p21waf/Cip and p53 and subsequently leads to cell death by the release of mitochondrial cytochrome c. The photoactivation of psoralen can also cause cell death by blocking oncogenic receptor tyrosine kinase signalling and the PI3K pathway by interfering with efficient recruitment of effector Akt kinase to the activated plasma membrane [ 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 ].…”

Section: Natural Photoactive Compounds From Plantsmentioning

confidence: 99%

Role of Photoactive Phytocompounds in Photodynamic Therapy of Cancer

et al. 2020

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Cancer is one of the greatest life-threatening diseases conventionally treated using chemo- and radio-therapy. Photodynamic therapy (PDT) is a promising approach to eradicate different types of cancers. PDT requires the administration of photosensitisers (PSs) and photoactivation using a specific wavelength of light in the presence of molecular oxygen. This photoactivation exerts an anticancer effect via apoptosis, necrosis, and autophagy of cancer cells. Recently, various natural compounds that exhibit photosensitising potentials have been identified. Photoactive substances derived from medicinal plants have been found to be safe in comparison with synthetic compounds. Many articles have focused on PDT mechanisms and types of PSs, but limited attention has been paid to the phototoxic activities of phytocompounds. The reduced toxicity and side effects of natural compounds inspire the researchers to identify and use plant extracts or phytocompounds as a potent natural PS candidate for PDT. This review focusses on the importance of common photoactive groups (furanocoumarins, polyacetylenes, thiophenes, curcumins, alkaloids, and anthraquinones), their phototoxic effects, anticancer activity and use as a potent PS for an effective PDT outcome in the treatment of various cancers.

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Treatment of cutaneous T-cell lymphoma (CTCL) by extracorporeal photochemotherapy

Cited by 2 publications

References 0 publications

Some Natural Photosensitizers and Their Medicinal Properties for Use in Photodynamic Therapy

Some Natural Photosensitizers and Their Medicinal Properties for Use in Photodynamic Therapy

Role of Photoactive Phytocompounds in Photodynamic Therapy of Cancer

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