ABSTRACT.Objective. There has been a large increase in reported cases of nonsynostotic plagiocephaly in infants since the adoption of supine sleeping recommendations to prevent sudden infant death syndrome. The objective of this study was to identify and quantify the determinants of nonsynostotic plagiocephaly in infants.Methods. One hundred infants who received a diagnosis of having nonsynostotic plagiocephaly were recruited as case patients and compared with 94 control subjects who were selected from a citywide database of infants. The infants all were aged between 2 and 12 months. Information concerning sociodemographic variables, obstetric factors, infant factors, and infant care practices was obtained by parental interview.Results. Case patients were significantly more likely to be male (adjusted odds ratio [ ABBREVIATIONS. SIDS, sudden infant death syndrome; NSP, nonsynostotic plagiocephaly; OR, odds ratio; SE, standard error; CI, confidence interval; aOR, adjusted odds ratio.