Treatment of corneal dermoid with lenticules from small incision lenticule extraction surgery: a surgery assisted by fibrin glue

Liu, Jiaolian; Ye, Qing; Wei, Liu-Qing; Zhong, Xia; Jiang, Lin-Zhi; Zeng, Jing

doi:10.18240/ijo.2023.04.08

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…But in recent years, the corneal lenticules which is a transplant layer from the intrastromal corneal tissue, might be a useful and simpler alternative corneal graft substitute. It was reported that SMILE-derived lenticule had been applied as corneal graft in several corneal dermoid surgeries, but its safety and feasibility is not clear till now 12 . Besides, due to the limited thickness of the corneal lenticules, overlapped multi-layer lenticules are required to repair the corneal defect.…”

Section: Introductionmentioning

confidence: 99%

Treatment of corneal dermoid with fibrin glue boned multi-layer lenticules derived from SMILE surgery

Li,

Cheng,

Jia

et al. 2024

Preprint

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Purpose Dermoid resection combined with lamellar keratoplasty was one of the most common surgical techniques for corneal dermoid. The aim of this preliminary study was to investigate the safety and feasibility of FG boned SMILE-derived multi-layer lenticules as corneal grafts to treat corneal dermoid. Methods 5 patients with corneal dermoid were involved in this study. All patients were treated with dermoid resection combined with FG boned multi-layer corneal lenticules transplantation. Ocular appearance, corneal grafts’ growth, location, epithelialization, transparency, and limbal pannus were assessed using slit lamp microscopy and anterior-segmental optical coherence tomography. The change of best-corrected visual acuity (BCVA) and astigmatism were examined preoperatively and postoperatively. Results Total of 5 patients were satisfied with the postoperative ocular appearance. All FG boned multi-layer lenticules grafts were successfully adhered to the corneal beds, without any dislocation or Interlayer separation. The lenticule grafts grew well and kept transparent during the follow-up time. Corneal epithelialization was observed in one week after transplantation, with smooth corneal epithelial coverage on the corneal surface, meanwhile, the grafts gradually merged with the recipient corneal stroma after 1mo post-operation. BCVA had been statistically improved from 0.36 ± 0.21 to 0.76 ± 0.17 in decimal at 3mo post-operation (Z=-2.060, P = 0.039). Postoperative corneal astigmatism also had been statistically decreased from 2.65 ± 0.42 D to 1.25 ± 0.18 D at 3mo postoperative (Z=-2.023, P = 0.043). Conclusion FG boned multi-layer lenticules would be the novel and feasible substitute for lamellar keratoplasty in the treatment of corneal dermoid. FG could not be only used as binder adhering multi-layer lenticules, closing the interlayer space of multi-layer lenticules, preventing the formation of interlayer fluid, but also increasing the thickness and toughness of lenticules, and therefore which is more facilitate to intraoperative suture.

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Section: Introductionmentioning

confidence: 99%

Treatment of corneal dermoid with fibrin glue boned multi-layer lenticules derived from SMILE surgery

Li,

Cheng,

Jia

et al. 2024

Preprint

View full text Add to dashboard Cite

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A Retrospective Analysis of Corneal Dermoid

Xuan,

Pei,

2024

Cureus

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Background: Corneal dermoid is a congenital benign tumor and ocular malformation, often diagnosed at birth or in early childhood. Its treatment and long-term prognosis remain under-researched, necessitating further investigation.Purpose: This study aims to investigate the epidemiological and clinical characteristics of corneal dermoid, evaluate the efficacy of different surgical methods, and identify factors influencing treatment outcomes.Methods: A retrospective analysis was conducted on the clinical data of 58 patients treated for corneal dermoid at our hospital from 2017 to 2021. Patients' demographic information, tumor characteristics, surgical methods, and postoperative outcomes were collected and analyzed. Descriptive statistics, independent sample t-test, chi-square (χ 2 ) test, and Spearman correlation analysis were used to evaluate the distribution characteristics and intergroup differences of corneal dermoid.Results: The average age of the patients was 6.3 years, with 55.2% being male and 44.8% female. The right eye was affected in 63.8% of cases, with the temporal limbus being the most common site (75.9%). Pathological examination revealed tumors covered by squamous epithelium, containing hair follicles, sebaceous glands, adipose tissue, and fibrous tissue; some cases also had cartilage and glandular tissue. Surgical methods included corneal dermoid excision (100%), lamellar keratoplasty (37.9%), amniotic membrane grafting (31.0%), and autologous limbal stem cell transplantation (8.6%). None of the 50 followed up patients experienced tumor recurrence. Postoperative vision improved in 58.0% of patients, with more females (61.9%) experiencing visual impairment compared to males (38.1%) (χ²=4.711, p=0.030).Conclusions: This study analyzed 58 corneal dermoid patients treated from 2017 to 2021, focusing on epidemiological and clinical characteristics, surgical efficacy, and treatment outcomes. It identified common pathological features and effective surgical methods, with no tumor recurrence in followed up patients. The study highlights the need for further research with larger sample sizes and longer follow-up periods.

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Treatment of corneal dermoid with lenticules from small incision lenticule extraction surgery: a surgery assisted by fibrin glue

Cited by 2 publications

References 30 publications

Treatment of corneal dermoid with fibrin glue boned multi-layer lenticules derived from SMILE surgery

Treatment of corneal dermoid with fibrin glue boned multi-layer lenticules derived from SMILE surgery

A Retrospective Analysis of Corneal Dermoid

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