Treatment of contagious caprine pleuropneumonia

Hassan, S. M. El; Harbi, M. S. M. A.; Bakr, M. I. Abu

doi:10.1007/bf02214697

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…Further, certain antibiotics used for treating CCPP affected animals also result in carriers (El Hassan et al. 1984; Spickler 2015). Antibiotics may not prevent persistence in latent carriers (Thiaucourt et al.…”

Section: Epidemiologymentioning

confidence: 99%

“…Several antibiotics have been used against Mccp for the treatment of CCPP (Onovarian 1974; El Hassan et al. 1984; Yatoo and Kanwar 2016; Yatoo et al. 2018).…”

Section: Treatmentmentioning

confidence: 99%

“…Then CCPP inoculated goats were treated with oxytetracycline or tylosin by El Hassan et al. (1984) which reduced severity, but 20% remained infectious. They used short acting oxytetracycline and tylosin at a dose rate of 10 and 20 mg/kg BW intramuscularly, respectively daily for 6 days, and single dose of long acting oxytetracycline at 20 mg/kg BW intramuscularly.…”

Section: Treatmentmentioning

confidence: 99%

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Contagious caprine pleuropneumonia – a comprehensive review

Yatoo

Parray

Bashir

et al. 2019

Veterinary Quarterly

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Contagious caprine pleuropneumonia (CCPP) is a serious disease of goats, occasionally sheep and wild ruminants, caused by Mycoplasma capricolum subspecies capripneumoniae (Mccp). The disease is characterized by severe serofibrinous pleuropneumonia, very high morbidity ($100%), and mortality (80-100%). CCPP affects goats in more than 40 countries of the world thereby posing a serious threat to goat farming around the globe. The characteristic clinical signs of CCPP are severe respiratory distress associated with sero-mucoid nasal discharge, coughing, dyspnea, pyrexia, pleurodynia, and general malaise. In later stages, severe lobar fibrinous pleuropneumonia, profuse fluid accumulation in pleural cavity, severe congestion of lungs and adhesion formation is observed. Mycoplasmal antigen interactions with host immune system and its role in CCPP pathogenesis are not clearly understood. CCPP is not a zoonotic disease. Diagnosis has overcome cumbersome and lengthy conventional tests involving culture, isolation, and identification by advanced serological (LAT, cELISA) or gene-based amplification of DNA (PCR, RFLP, and hybridization) and sequencing. The latex agglutination test (LAT) is rapid, simple, and better test for field and real-time diagnosis applicable to whole blood or serum and is more sensitive than the CFT and easier than the cELISA. Moreover, the studies on antibiotic sensitivity and exploration of novel antibiotics (fluoroquinolones, macrolides) can help in better therapeutic management besides preventing menace of antibiotic resistance. Re-visiting conventional prophylactic measures focussing on developing novel strain-based or recombinant vaccines using specific antigens (capsular or cellular) should be the most important strategy for controlling the disease worldwide.

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Section: Epidemiologymentioning

confidence: 99%

“…Several antibiotics have been used against Mccp for the treatment of CCPP (Onovarian 1974; El Hassan et al. 1984; Yatoo and Kanwar 2016; Yatoo et al. 2018).…”

Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

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Contagious caprine pleuropneumonia – a comprehensive review

Yatoo

Parray

Bashir

et al. 2019

Veterinary Quarterly

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“…In countries where vaccination is not practised, other control measures are used. Antibiotics such as the tetracyclines, fluoroquinolones and the macrolide family are generally clinically effective if used early enough (Onovarian, 1974; Hassan et al., 1984; Ozdemir et al., 2006). However, the complete elimination of the mycoplasma is rarely achieved, and treated animals are considered to be potential carriers.…”

Section: Disease Prevention and Controlmentioning

confidence: 99%

Contagious Caprine Pleuropneumonia: New Aspects of an Old Disease

Nicholas

Churchward

2011

Transboundary and Emerging Diseases

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Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae, is a serious OIE-listed disease affecting goats in the Middle East, north and east Africa and Asia. Mortality and morbidity rates can be as high as 60% and 90%, respectively, when the disease first enters a territory, invariably through carrier animals. Recent detections of CCPP in Pakistan and Tajikistan are probably the result of improved diagnosis as the disease has been suspected there for many years, while those in Thrace in 2003 and Mauritius in 2009 represent new outbreaks. CCPP was thought to be highly host specific until recent outbreaks in wildlife species including gazelles and gerenuks show that the causative mycoplasma has broader specificity. Diagnosis was hampered by the fastidiousness of the causative mycoplasma but molecular-based tests like PCR have greatly improved detection. Rapid latex agglutination tests that can be performed at the penside are also available for antibody detection. Clinically affected animals respond to a range of antibiotics although it is unlikely that this results in complete elimination of the mycoplasma. Vaccines consisting of saponized organisms have been shown to be protective but the quality and efficacy may be variable.

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Respiratory System

Diplomate

Sherman

2009

Goat Medicine

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Treatment of contagious caprine pleuropneumonia

Cited by 11 publications

References 5 publications

Contagious caprine pleuropneumonia – a comprehensive review

Contagious caprine pleuropneumonia – a comprehensive review

Contagious Caprine Pleuropneumonia: New Aspects of an Old Disease

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