Treatment of Congenital Syphilis with Penicillin

Platou, R. V.

doi:10.1016/s0065-3101(22)00810-6

Cited by 27 publications

(1 citation statement)

References 19 publications

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“…The inset is a typical centrilobular region from this biopsy; the arrow points out one of many giant cells (H&E x 100). mortem examination (2,8,11). Prior to the introduction of penicillin treatment , hep atiti s was rare.…”

Section: Discussionmentioning

confidence: 99%

Clinical Manifestations of Congenital Syphilitic Hepatitis

Long,

Ulshen,

Lawson

1984

J. pediatr. gastroenterol. nutr.

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To study the clinical course and biochemical features of congenital syphilitic hepatitis, the records of all 22 pediatric patients admitted to North Carolina Memorial Hospital between 1969 and 1979 with a positive maternal, cord blood, or serum VDRL were reviewed. Of the seven infants identified with symptomatic congenital syphilis, five had clinical and biochemical evidence of liver dysfunction. All five were jaundiced (peak bilirubin ranged from 8.4 to 29.8 mg/dl, in each case >40% conjugated). Peak transaminase elevation ranged from seven to 150 times normal. Serum glutamic‐oxaloacetic transaminase exceeded serum glutamic‐pyruvic transaminase in each infant, the difference ranging to 7,400 U. The onset of illness did not occur until after treatment had been initiated in two of these five cases. Liver dysfunction increased with treatment in all four infants with serial enzyme determinations. Liver dysfunction also persisted for more than 6 weeks after adequate treatment in two cases. Liver biopsy 5 weeks after treatment in another infant showed giant cell hepatitis. These observations suggest that treatment can potentiate liver dysfunction in congenital syphilis and that viable treponemes are not necessarily essential in the pathogenesis of the hepatitis.

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Section: Discussionmentioning

confidence: 99%

Clinical Manifestations of Congenital Syphilitic Hepatitis

Long,

Ulshen,

Lawson

1984

J. pediatr. gastroenterol. nutr.

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Antibiotic treatment for newborns with congenital syphilis

Walker

Molano-Franco

et al. 2019

Cochrane Database of Systematic Reviews

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BackgroundCongenital syphilis continues to be a substantial public health problem in many parts of the world. Since the first use of penicillin for the treatment of syphilis in 1943, which was a notable early success, it has remained the preferred and standard treatment including for congenital syphilis. However, the treatment of congenital syphilis is largely based on clinical experience and there is extremely limited evidence on the optimal dose or duration of administration of penicillin or the use of other antibiotics. ObjectivesTo assess the e ectiveness and safety of antibiotic treatment for newborns with confirmed, highly probable and possible congenital syphilis. Search methodsWe searched the Cochrane STI Group Specialized Register, CENTRAL, MEDLINE, Embase, LILACS, WHO ICTRP, ClinicalTrials.gov and Web of Science to 23 May 2018. We also handsearched conference proceedings, contacted trial authors and reviewed the reference lists of retrieved studies. Selection criteriaRandomised controlled trials (RCTs) comparing antibiotic treatment (any concentration, frequency, duration and route) with no intervention or any other antibiotic treatment for neonates with confirmed, highly probable or possible congenital syphilis. Data collection and analysisAll review authors independently assessed trials for inclusion, extracted data and assessed the risk of bias in the included studies. We resolved any disagreements through consensus. We assessed the quality of the evidence using the GRADE approach. Main resultsTwo RCTs (191 participants) met our inclusion criteria and none of these trials was funded by the industry. One trial (22 participants) compared benzathine penicillin with no intervention for infants with possible congenital syphilis. Low-quality evidence suggested that benzathine penicillin administration may not have decreased the rate of neonatal death due to any cause (risk ratio (RR) 0.83, 95% confidence interval (CI) 0.06 to 11.70), and showed a possible reduction into the proportion of neonates with clinical manifestations of congenital syphilis (RR 0.12, 95% CI 0.01 to 2.09). Penicillin administration increased the serological cure at the third month (RR 2.13, 95%Antibiotic treatment for newborns with congenital syphilis (Review)

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Clutton's joints with keratitis and periostitis a case report with histology of synovium

Argen

Dixon

1963

Arthritis & Rheumatism

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A case of Clutton's joints or chronic synovitis as a late manifestation of congenital syphilis is presented. Progressive patchy periostitis and interstitial keratitis were also present in this 19-year-old-Negro girl. All three manifestations of the disease and the serology were apparently unaffected by penicillin therapy. The histology of the synovium is presented and illustrated. This report presents a case of Clutton's joints with interstitial keratitis and periostitis which was unresponsive to penicillin therapy. Histology of the synovium has been described in the literatures and is here further illustrated. Laboratory examinations on admission showed a normal hematocrit, white blood cell count, differential count and urinalysis. Other studies which were normal include blood CASE REPORT

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Treatment of Congenital Syphilis with Penicillin

Cited by 27 publications

References 19 publications

Clinical Manifestations of Congenital Syphilitic Hepatitis

Clinical Manifestations of Congenital Syphilitic Hepatitis

Antibiotic treatment for newborns with congenital syphilis

Clutton's joints with keratitis and periostitis a case report with histology of synovium

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