“…Various different treatments, alone, or in association, including bisphosphonate, analgesic, local anethetics, physical therapy and neuromodulation have been proposed, with different, but not satisfactory, results. 3,4 Recently a double-blind placebo controlled study showed the efficacy of neridronate to reduce pain of 50% at 40 days after treatment. This study represents, so far, the best-controlled clinical evidence of therapeutic effect.…”