Treatment of Comorbid Obesity and Major Depressive Disorder: A Prospective Pilot Study for their Combined Treatment

Faulconbridge, Lucy F.; Wadden, Thomas A.; Berkowitz, Robert I.; Pulcini, Melissa E.; Treadwell, Thomas

doi:10.1155/2011/870385

Cited by 21 publications

(17 citation statements)

References 22 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Obesity and depression have bi-directional relationship and they often occur together [39], however, there have been no studies on combination therapy among individuals with obesity and depression. In a pilot study it was documented that individuals who were provided CBT for depression along with evidence-based behavioral treatment for obesity achieved a clinically significant reduction in depressive symptoms in 16 weeks [40]. Therefore, it is plausible that those with obesity and depression may receive treatments that combine psychotherapy for depression to achieve better clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Depression treatment patterns among individuals with osteoarthritis: a cross sectional study

2013

View full text Add to dashboard Cite

BackgroundArthritis and depression often co-occur; however, studies that describe patterns of depression treatment among individuals with arthritis are scant. The purpose of the study was to examine depression treatment patterns among individuals with osteoarthritis (OA) by predisposing, enabling, need factors, personal health practices and external health environment.MethodsRetrospective cross-sectional design was used. Data were obtained from 2008 and 2010 Medical Expenditure Panel Survey (MEPS). The sample consisted of 647adults aged over 21 years with depression and OA. Depression treatment was categorized as: 1) No treatment;2) antidepressant use only and 3) both antidepressants and psychotherapy (combination therapy). Chi- square tests and multinomial logistic regressions were used to describe patterns of depression treatment. All analysis was performed using Statistical Analysis Software (SAS) version 9.3.ResultsOverall, 13.0% of the study sample reported no depression treatment, 67.8% used antidepressants only and 19.2% used combination therapy. Among individuals with OA significant subgroup differences in depression treatment were observed. For example, African Americans were less likely to report depression treatment compared to whites [antidepressants: AOR=0.33, 95% CI=0.21,0.51; combination therapy: AOR=0.39, 95% CI=0.23, 0.65]. Elderly adults were more likely to receive antidepressants and less likely to receive psychotherapy as compared to younger adults [AOR=0.53, 95% CI= 0.28,0.98]. Adults with anxiety were more likely to report depression treatment compared to those without anxiety [antidepressants: AOR=1.53, 95% CI=1.06, 2.22; combination therapy: AOR=3.52, 95% CI=2.40, 5.15].ConclusionFuture research needs to examine the reason for low rates of combination therapy as well as subgroup differences in combination therapy among individuals with OA.

show abstract

Section: Discussionmentioning

confidence: 99%

Depression treatment patterns among individuals with osteoarthritis: a cross sectional study

2013

View full text Add to dashboard Cite

show abstract

“…These results provided initial evidence that obese individuals with MDD could lose weight. More encouraging results were yielded by Faulconbridge and colleagues [107•] who conducted a pilot study with 12 obese, depressed individuals who received a combination of lifestyle modification for their obesity and cognitive-behavioral therapy for their depression for 16 weeks. The mean weight loss among those who completed the study was 11.4% of initial weight, comparable to the magnitude of weight loss observed in non-depressed participants undergoing lifestyle modification interventions [100].…”

Section: Outcomes For Depressed Individuals In Weight Loss Trialsmentioning

confidence: 99%

“…As such, it may be prudent to moderate the weight loss expectations of depressed individuals undertaking weight reduction. In addition, a small minority of patients do experience adverse psychological events during weight loss [89,107], and thus careful monitoring of mood in all individuals who undertake weight loss is advisable.…”

Section: Outcomes For Depressed Individuals In Weight Loss Trialsmentioning

confidence: 99%

Depression and Disordered Eating in the Obese Person

Faulconbridge

Bechtel

2013

Curr Obes Rep

Self Cite

View full text Add to dashboard Cite

Three mental health problems commonly associated with obesity are major depression, binge eating disorder (BED), and Night Eating Syndrome (NES). Evidence from both cross-sectional and longitudinal studies support independent relationships between obesity and depression, and between obesity and binge eating. These problems are most prevalent in severely obese individuals (Class III obesity; a body mass index (BMI) of >40kgm2), many of whom seek bariatric surgery, and we briefly review whether the presence of pre-operative depression, BED or NES affects post-operative outcomes. Historically depressed individuals have been screened out of weight loss trials due to concerns of worsening mood with weight loss. Such practices have precluded the development of effective treatments for depressed, obese individuals, leaving large numbers of people without appropriate care. We present recent advances in this area, and attempt to answer whether depressed individuals can lose clinically significant amounts of weight, show improvements in mood, and adhere to the demands of a weight loss intervention.

show abstract

“…[7] An uncontrolled trial evaluated simultaneous lifestyle intervention and CBT for depression reported much larger weight loss (i.e., mean weight loss of −10.4 kg) than typically observed in either depressed or nondepressed samples but only included 9 participants. [8] Another small uncontrolled trial tested the simultaneous delivery of a lifestyle intervention and brief behavior therapy for depression in 14 individuals [9] and found significant changes in weight and depression, however weight loss was also modest (i.e., mean = −2.5 kg) relative to nondepressed samples. [7] Given that the bulk of the evidence shows that people with depression lose less weight than their non-depressed counterparts, specialized interventions appear to be needed.…”

Section: Introductionmentioning

confidence: 99%

Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial

et al. 2013

View full text Add to dashboard Cite

Objective Depression is associated with increased risk for obesity and worse weight loss treatment outcomes. The purpose of the present study was to test the hypothesis that delivering evidence-based behavior therapy for depression prior to a lifestyle weight loss intervention improves both weight loss and depression. Design In a randomized controlled trial, obese women with major depressive disorder (N=161, mean age=45.9 [SD: 10.8] years) were randomized to brief behavior therapy for depression treatment followed by a lifestyle intervention (BA) or a lifestyle intervention only (LI). Follow-up occurred at 6- and 12-months. Main outcome measures included weight loss and depression symptoms. Results Intention-to-treat analyses revealed both conditions lost significant weight, but no differences between conditions in weight change at 6-months (BA= −3.0%, SE= − 0.65%; LI=−3.7%, SE = 0.63%; p = 0.48) or 12-months (BA= −2.6%, SE= 0.77%; LI= −3.1%, SE=0.74%; p= 0.72). However, the BA condition evidenced significantly greater improvement in Beck Depression Inventory-II scores relative to the LI condition at both 6-months (BA mean change= −12.5, SD= 0.85; LI mean change= −9.2, SD=0.80, p= 0.005) and 12-months (BA mean change= −-12.6, SD= 0.97; LI mean change= −9.9, SD= 0.93; p = 0.045). Participants who experienced depression remission by 6-months (61.2%) lost greater weight (mean = −4.31%; SE=0.052) than those who did not (39.7%; mean= −2.47%, SE=0.53; p=.001). Conclusion Adding behavior therapy to a lifestyle intervention results in greater depression remission but does not improve weight loss within one year. Improvement in depression is associated with greater weight loss.

show abstract

Treatment of Comorbid Obesity and Major Depressive Disorder: A Prospective Pilot Study for their Combined Treatment

Cited by 21 publications

References 22 publications

Depression treatment patterns among individuals with osteoarthritis: a cross sectional study

Depression treatment patterns among individuals with osteoarthritis: a cross sectional study

Depression and Disordered Eating in the Obese Person

Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial

Contact Info

Product

Resources

About