Treatment of clomiphene citrate‐related ovarian cysts in a prospective randomized study. A single center experience

Altınkaya, Sündüz Özlem; Talas, Betul Bayir; Güngör, Tayfun; Gülerman, Cavidan

doi:10.1111/j.1447-0756.2009.01041.x

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…Functional ovarian cysts have often been observed after ovulation induction. 10 High order multiple pregnancy rates are also found to be increased due to CC treatment. Moreover, ovarian hyperstimulation syndrome is a potentially serious complication of ovulation induction.…”

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confidence: 78%

“…Functional ovarian cysts, ovarian hyperstimulation syndrome, and thinning of the endometrium are some of them. 10,11,24 In recent years, fears of cancer possibility induced by ovulation inducing agents have been raised and addressed by various study reports. 25 Among ovulation inducing agents, CC has been implicated in the etiology of genital organ cancers and breast cancer.…”

Section: Discussionmentioning

confidence: 99%

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The Histopathological Changes in Rat Ovary and Endometrium Following Long Term Clomiphene Treatment

Özdemır¹,

Erol²,

Cevrioğlu³

et al. 2015

Turkiye Klinikleri J Med Sci

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lomiphene citrate (CC) a nonsteroidal tissue selective estrogen receptor modulator was approved for clinical use in 1967. [1][2][3] CC is the first line treatment for women with ovulatory disorders who are Turkiye Klinikleri J Med Sci 2015;35(4) 209 The Histopathological Changes in Rat Ovary and Endometrium Following Long Term Clomiphene Treatment A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Clomiphene citrate (CC) a nonsteroidal tissue selective estrogen receptor modulator is used for inducing ovulation. In this study, we aimed to investigate the histopathological changes and dose related effects of long term CC treatment on rat ovary and endometrium. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Four groups of female rats were included in the study. In group 1 (control) only saline was administered whereas in groups 2, 3 and 4 CC was (once a week) administered for 18 weeks at the doses of 1 mg/kg, 4 mg/kg and 8 mg/kg, respectively. Uterus and both ovaries were excised for histopathological evaluation. R Re es su ul lt ts s: : Histopathological examination showed that papillary hyperplasia of the surface epithelium of the ovary was present in all CC treated groups, with the highest percentage and severity in group 4. The mean values of endometrial thickness and endometrial gland diameters in this group were lower than those in groups 1 and 2 (p<0.05). Diameters of ovaries and ovarian surface epithelium in group 4 were decreased with respect to control group (p<0.05). C Co on nc cl lu us si io on n: : High doses and repetitive treatment with CC may have detrimental effects in terms of endometrial thinning and developing precancerous lesions in the ovaries.K Ke ey y W Wo or rd ds s: : Clomiphene; pathology; endometrium; ovary; rats; time Ö ÖZ ZE ET T A Am ma aç ç: : Klomifen sitrat (CC) ovulasyon indüksiyonunda kullanılan, steroid yapıda olmayan, seçici özellikte östrojen reseptör modülatörüdür. Bu çalışmada, uzun süreli CC tedavisinin rat ovaryumu ve endometriyumundaki histopatolojik değişikliklerin uygulanan dozla ilişkisi araştırıldı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma her grupta yedi dişi rat bulunan dört grupta yapıldı. Grup 1'e (kontrol) fizyolojik tuzlu su verilirken grup 2, 3 ve 4'e klomifen sitrat sırasıyla 1 mg/kg, 4 mg/kg ve 8 mg/kg dozlarda 18 hafta boyunca haftada bir kez oral yolla uygulandı. Çalışmanın sonunda uterus ve her iki ovaryum histopatolojik değerlendirmeler için eksize edildi. B Bu ul lg gu ul la ar r: : Histopatolojik çal-ışmalar, klomifen sitrat uygulanan bütün grupların ovaryum yüzey epitellerinde papiller hiperplazi meydana geldiğini gösterdi; grup 4'te papiller hiperplazinin şiddeti ve yüzdesi daha yüksek belirlendi. Bu grupta endometrial bezlerin çapları ve endometrial kalınlıklarının ortalama değerlerinin grup 1 ve grup 2'den daha düşük olduğu bulundu (p<0,05). Grup 4'teki ovaryum yüzey epiteli ve ovaryum çapları da kontrol grubu ile karşılaştırıldığında azaldığı saptandı (p<0,05). S So on nu uç ç: : Yüksek dozda ve uzun süreli...

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mentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

The Histopathological Changes in Rat Ovary and Endometrium Following Long Term Clomiphene Treatment

Özdemır¹,

Erol²,

Cevrioğlu³

et al. 2015

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

show abstract

“…9 Combined oral contraceptives (COCs) are frequently prescribed to women with ovarian cysts. Multiple randomized controlled trials have been performed and demonstrated that COCs do not expedite cyst resolution [10][11][12][13][14][15] ; however, COCs may prevent additional functional cysts from developing. Current evidence does not support COC administration for treatment of functional cysts.…”

Section: Managementmentioning

confidence: 99%