Treatment of clinical endometritis in dairy cows by previously used controlled internal drug release devices

Eslami, Mohsen; Bolourchi, M.; Seifi, Hesam A; Asadi, Farzad; Akbari, Rahmat

doi:10.1016/j.theriogenology.2015.03.036

Cited by 12 publications

(11 citation statements)

References 44 publications

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“…Cytokines have been detected in the serum, uterine tissue, and uterine flushing of animals with endometritis . A problem that arises in the first 3 weeks in post‐natal cows is the occurrence of endometritis . This period of time contributes to inhibited reproduction leading to infertility and increased economic losses.…”

Section: Discussionmentioning

confidence: 99%

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Nisin reduces uterine inflammation in rats by modulating concentrations of pro‐ and anti‐inflammatory cytokines

Jia

Wang

et al. 2019

American J Rep Immunol

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Problem The Staphylococcus aureus has been found to be associated with clinical endometritis of cow. The result of oral antibiotic remains poor. Therefore, this study investigates the role of nisin in endometritis. Method of study The effect of nisin on the growth and cell wall of S aureus were determined in vitro. Besides the blank control group, animals with established post‐partum were inoculated with 0.1 mL S aureus intravaginally. Two days post‐inoculation, the animals were administered nisin (25 mg/kg), kanamycin (30 mg/kg), and water (model group) for 7 days. On the seventh day, serum and uterine organs were obtained for pro‐ and anti‐inflammatory analysis. The uterine tissue samples were weighed, and histopathological analysis was performed. Results The results showed that nisin had an inhibitory effect on the growth and cell wall formation of S aureus. Nisin and kanamycin treatment prevented a S aureus‐induced decrease in pro‐inflammatory cytokines and promoted an increase in the level of serum anti‐inflammatory cytokines in the endometrium of these animals. Nisin and kanamycin, significantly decreased (P < 0.05) the endometritis‐induced increases in uterine weight, restored endometrial architecture and significantly (P < 0.05) normalized uterine neutrophils to control levels. Additionally, improved levels of B7‐2, IFN‐γ, IL‐2, and IL‐8 were observed when treated with nisin. Conclusion Our findings suggest that nisin compared favorably with kanamycin in endometritis prevention, suggesting that nisin can be used in S aureus‐induced endometritis by protecting the uterus from S aureus infection.

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Section: Discussionmentioning

confidence: 99%

“…At present, although antibiotics are widely used in the treatment of cow endometritis, it is very easy to change the immunity of livestock itself . Therefore, there is an urgent need to research and develop natural and green substances …”

Section: Introductionmentioning

confidence: 99%

Nisin reduces uterine inflammation in rats by modulating concentrations of pro‐ and anti‐inflammatory cytokines

Jia

Wang

et al. 2019

American J Rep Immunol

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“…Although many of the reproductive problems in dairy cows result from diseases such as uterine infections (Bell & Roberts, 2007;Sheldon et al, 2008;Esalami et al, 2015) and occurrence of other postpartum reproductive problems, such as retained placenta, uterine prolapse, and postpartum uterine haemorrhage, the effect of metabolic stress, which is associated with high milk yield, on reproductive performance has received great interest among dairy practitioners and researchers (Collard et al, 2000;Fleischer et al, 2001;Raboisson et al, 2014). The fertility traits (PPP, S/C, OP, CR, and CR to first service) that were considered in this study are those which are usually used by dairy practitioners to evaluate the reproductive performance of dairy cows (Kaewlamun et al, 2001;Abdel Gader et al, 2007;Walsh et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Association between postpartum blood levels of glucose and urea and fertility of cross-bred dairy cows in Sudan

Sulieman¹,

Makawi²,

Ibrahim³

2017

SA J. An. Sci.

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This study aimed to find correlations between blood glucose and urea levels and the duration of postpartum period (PPP), number of services per conception (S/C), open period (OP), conception rate (CR) to first service, and the overall CR in 80 multiparous cross-bred dairy cows. The two metabolites were measured 1, 4, 7, 10, and 13 weeks postpartum. The CR to first service and overall CR were 13.8% and 42.8%, respectively. Based on S/C, three groups were identified: Group 1 (G-1) (n = 11) consisting of cows that conceived from first service; G-2 (n = 46) representing cows that needed two inseminations to conceive; and G-3 (n = 23) consisting of repeat breeders (RB). G-1 represented 13.8%, with PPP and OP shorter than cows in G-2 and in G-3, and had blood glucose levels 17.5% and 27.9% higher than levels in G-2 and in G-3, respectively. Until the 7th week postpartum, blood levels of urea were higher in G-1 and lower in G-3. However, in the 10th and 13th weeks postpartum, results were reversed. The PPP, S/C, and OP were negatively correlated with blood glucose over the study period and with blood urea at the first seven weeks postpartum. However, these traits were positively correlated with blood urea measured at 10 and 13 weeks postpartum. It can be concluded that, from this study, maintaining high blood glucose until the 13th week postpartum, high blood urea during the first 7 weeks postpartum, and low blood urea during the 10th and 13th weeks postpartum were associated with good fertility in dairy cows. ______________________________________________________________________________________

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“…Endometritis, defined as inflammation of the uterus, is a prevalent disease in high-producing dairy cows and consequently results in economic losses [1, 2]. The endometrium is the first line of defense against invading pathogenic microorganisms, which cause histological lesions and inflammation of the endometrium [3].…”

Section: Introductionmentioning

confidence: 99%

Thymol mitigates lipopolysaccharide-induced endometritis by regulating the TLR4- and ROS-mediated NF-κB signaling pathways

Jiang

Yin

et al. 2017

Oncotarget

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The purpose of this study was to investigate the effects of thymol on lipopolysaccharide (LPS)-induced inflammatory responses and to clarify the potential mechanism of these effects. LPS-induced mouse endometritis was used to confirm the anti-inflammatory action of thymol in vivo. RAW264.7 cells were used to examine the molecular mechanism and targets of thymol in vitro. In vivo, thymol markedly alleviated LPS-induced pathological injury, myeloperoxidase (MPO) activity, and the production of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in mice. Further studies were performed to examine the expression of the Toll-like receptor 4 (TLR4) -mediated nuclear factor-κB (NF-κB) pathway. These results showed that the expression of the TLR4-mediated NF-κB pathway was inhibited by thymol treatment. In vitro, we observed that thymol dose-dependently inhibited the expression of TNF-α, IL-1β, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) in LPS-stimulated RAW264.7 cells. Moreover, the results obtained from immunofluorescence assays also indicated that thymol dose-dependently suppressed LPS-induced reactive oxygen species (ROS) production. Silencing of TLR4 inhibited NF-κB pathway activation. Furthermore, H2O2 treatment increased the phosphorylation of p65 and IκBα, which were decreased when treated with N-acetyl cysteine or thymol. In conclusion, the anti-inflammatory effects of thymol are associated with activation of the TLR4 or ROS signaling pathways, contributing to NF-κB activation, thereby alleviating LPS-induced oxidative and inflammatory responses.

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Treatment of clinical endometritis in dairy cows by previously used controlled internal drug release devices

Cited by 12 publications

References 44 publications

Nisin reduces uterine inflammation in rats by modulating concentrations of pro‐ and anti‐inflammatory cytokines

Nisin reduces uterine inflammation in rats by modulating concentrations of pro‐ and anti‐inflammatory cytokines

Association between postpartum blood levels of glucose and urea and fertility of cross-bred dairy cows in Sudan

Thymol mitigates lipopolysaccharide-induced endometritis by regulating the TLR4- and ROS-mediated NF-κB signaling pathways

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