Treatment of Chronic Salmonella Carriers

Abstract

The present stage of our studies suggests that, provided a highly effective combined therapy is, and can be, carried out correctly, all excreters can be cured of their chronic carrier state by chemotherapy within 8–12 weeks. Although we cannot recommend a universal therapeutic regimen for all patients, a highly effective ‘basic therapy’ (RMP+TSP) is available for the majority of the cases, needing occasional modification, depending on the specific requirements of the individual patient as shown by the result of the serum activity determination. This method saves the patient from toxic inconveniences caused by inadequate treatment, it shortens the treatment time and makes cholecystectomy superfluous – unless it is considered necessary out of a different indication in which case it should certainly be done. We cannot share the often expressed view that Salmonella enteritidis excreters cannot be cured, a view which is found even in the most recent manuals. The same applies to the view that therapy is not necessary because it would delay cure. It is indispensable to establish a close cooperation between the public health authorities and the private physician, and we therefore wish to sincerely thank all colleagues and Public Health Officers for their collaboration.

The Role of WHO in Antileprosy Drug Trials

“…(d) To explore further the advantages of combined drug therapy on the lines pioneered by Freerksen and colleagues (Freerksen and Rosenfeld, 1973), keeping in mind what has already been mentioned under desirable properties of antileprosy drugs.…”

Curing of Typhoid Carriers by Cholecystectomy Combined with Amoxycillin plus Probenecid Treatment

“…On the basis of our materi al, too, these results were realized. In rigor ously controlled material, there appeared more favourable results due to cholecystec tomy combined with antibiotic treatment [1,5,6,9,10,14,17]. In this respect, Klose et al [7] started a new period when they achieved a 100% cure rate by cholecystecto my combined with high-dose benzylpenicillin treatment.…”