Treatment of Chronic Rhinosinusitis with High-Dose Oral Terbinafine: A Double Blind, Placebo-Controlled Study

Kennedy, David W.; Kühn, Frederick A.; Hamilos, Daniel L.; Zinreich, S. James; Butler, D.; Warsi, Ghulam; Pfister, Pascal; Tavakkol, Amir

doi:10.1097/01.mlg.0000175683.81260.26

Cited by 108 publications

(74 citation statements)

References 13 publications

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“…361,376 Numerous studies, including multiple RCTs, have examined the role of antifungal treatment in CRS and none have shown a clinically meaningful improvement. [377][378][379][380][381] Although not directly addressing fungus as an etiologic factor, these clinical studies cast significant doubt on the role of fungus in the etiology of CRS.…”

Section: S55mentioning

confidence: 99%

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International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: S55mentioning

confidence: 99%

“…379 Kennedy et al 379 recruited 53 adult CRS patients and randomized them into 2 groups in a DBRCT. Patients who had sinus surgery within the 3 months prior to screening were not considered for this study.…”

Section: S93mentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

View full text Add to dashboard Cite

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“…However, it is often pointed out that this system lacks sufficient levels of gradation for tracking progression or reduction of the disease volume [5]. Three more detailed staging systems, which are modifications of the L-M system, have been reported in recent years to help resolve these deficiencies [5][6][7].…”

Section: Discussionmentioning

confidence: 99%

The Toho Score: A New Evaluation System for Chronic Sinusitis Using Computed Tomography with Ziostation

Ota¹,

Odashima²,

Terada³

et al. 2016

UCMS

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OBJECTIVE: We tried a new system for the evaluation of chronic sinusitis (CS) that uses a Computed tomography (CT) system equipped with the Ziostation 2 (Zio 2). SUBJECTS AND METHODS: Subjects were selected from patients with CS who had been evaluated using a CT system equipped with the Zio 2. Participants included 10 CS patients, 20 sides. The percentage of the volume of the soft-tissue density area relative to the total volume (STDA%) was calculated using Zio 2 system. We named this STDA% determined using the Zio 2 system the "Toho score." Two doctors carried out these evaluations, and their results were compared. Toho score was compared with the Lund-Mackay (L-M) score. RESULTS: The Toho scores were correlated between the two doctors with significance (the correlation coefficients of total paranasal sinus area, 0.95). They were correlated with the corresponding L-M score values with significance, too (the correlation coefficients of total paranasal sinus area, 0.82). CONCLUSION: Toho system may be useful for accurately determining the extent of the inflammatory lesion in the paranasal sinus. In future, it can be employed effectively for monitoring treatment effects in chronic sinusitis and other conditions that involve inflammation of the paranasal sinuses.

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“…47,48 Three more trials were included in this review. 36,37,39 No meta-analysis was performed in the study by Lim et al 46 Rather, it was purely qualitative.…”

Section: Discussionmentioning

confidence: 99%

“…All trials were free of selective reporting. All but one trial 39 provided an allocation table or otherwise stated that the two groups were similar at baseline. It was noted that the Mayo Clinic is a collaborative partner with Accentia Biopharmeuticals, a company that holds the worldwide, exclusive commercial rights to SinuNase (topical amphotericin B, Accentia Biopharmaceuticals, Tampa, FL), 26 and that Ponikau holds a patent for this product.…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%