“…The early results of albumin therapy in the nephrotic syndrome were disappointing, and -this was thought to be due to loss of most of the infused protein in the urine (Janeway et al, 1944;Leutscher et al, 1949). Moreover, albumin was expensive and difficult to obtain, and thus its use was virtually abandoned in favour of other agents, such as mannitol, dextran, and povidone, many of which proved {to have undesirable side effects (Rennie, 1956). From this study it appears rthat albumin infusions musit be used in conjunction with effective diuretic (therapy, as very little of the sodium and water mobilized from the interstitial space is excreted unless a diuretic is given ( fig.…”