Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder

Tetz, George; Kardava, K; Vecherkovskaya, Maria; Tsifansky, Michael D.; Tetz, Victor

doi:10.22541/au.166930354.45120851/v1

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…More recently, we reported the case of a patient who, after renal cancer surgery, developed a recurrent urinary tract infection despite multiple antibiotic courses selected with antibiotics selected with conventional tests. The infection was successfully eradicated once antibiotics were selected with AtbFinder ( 35 , 36 ). In the present study, we provide a prospective evaluation of the effectiveness of antibiotics selected with AtbFinder compared to a retrospective analysis of antibiotic efficacy selected with conventional culture-based AST in patients with CF, a paradigm disease for studying chronic, complex polymicrobial human infections ( 37 ).…”

Section: Introductionmentioning

confidence: 99%

AtbFinder Diagnostic Test System Improves Optimal Selection of Antibiotic Therapy in Persons with Cystic Fibrosis

Tetz¹,

Kardava²,

Vecherkovskaya³

et al. 2023

J Clin Microbiol

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Section: Introductionmentioning

confidence: 99%

AtbFinder Diagnostic Test System Improves Optimal Selection of Antibiotic Therapy in Persons with Cystic Fibrosis

Tetz¹,

Kardava²,

Vecherkovskaya³

et al. 2023

J Clin Microbiol

Self Cite

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Overcoming Antibiotic Resistance with Novel Paradigms of Antibiotic Selection

Tetz¹,

Tetz²

2022

Microorganisms

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Conventional antimicrobial susceptibility tests, including phenotypic and genotypic methods, are insufficiently accurate and frequently fail to identify effective antibiotics. These methods predominantly select therapies based on the antibiotic response of only the lead bacterial pathogen within pure bacterial culture. However, this neglects the fact that, in the majority of human infections, the lead bacterial pathogens are present as a part of multispecies communities that modulate the response of these lead pathogens to antibiotics and that multiple pathogens can contribute to the infection simultaneously. This discrepancy is a major cause of the failure of antimicrobial susceptibility tests to detect antibiotics that are effective in vivo. This review article provides a comprehensive overview of the factors that are missed by conventional antimicrobial susceptibility tests and it explains how accounting for these methods can aid the development of novel diagnostic approaches.

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Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder

Cited by 2 publications

References 15 publications

AtbFinder Diagnostic Test System Improves Optimal Selection of Antibiotic Therapy in Persons with Cystic Fibrosis

AtbFinder Diagnostic Test System Improves Optimal Selection of Antibiotic Therapy in Persons with Cystic Fibrosis

Overcoming Antibiotic Resistance with Novel Paradigms of Antibiotic Selection

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