Treatment of chronic posterior blepharitis after allogeneic hematopoietic stem cell transplantation (a case report)

Safonova, T N; Kintyukhina, N P

doi:10.17116/oftalma202013602186

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…As shown, blepharitis was the main condition detected in the study population, being recognised as the most common regardless of age, ethnicity, and sex [31]. Although this condition is not vision-threatening, if left untreated it can cause keratopathy, neovascularisation, corneal ulceration, and others [32][33][34][35]. Comorbidities such as diabetes mellitus, high blood pressure, as well as chronic degenerative diseases such as cancer are added as susceptibility factors for the acquisition of eye infections.…”

Section: Discussionmentioning

confidence: 99%

Molecular Characterization of Bacterial Agents Causing External Ocular Infections Isolates of Patients in a Third Level Hospital

Durán-Manuel,

Bello-López,

Salinas-Bobadilla

et al. 2023

Pathogens

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Empirical use of antibiotics in the treatment of eye infections leads to bacterial pathogens becoming resistant to antibiotics; consequently, treatment failure and eye health complications occur. The aim of this study was to describe the phenotype and genotype of the resistance and adherence of bacterial agents causing eye infections in patients at Hospital Juárez de México. An observational, prospective, cross-sectional, and descriptive study was carried out in patients with signs and symptoms of ocular infection. Bacterial agents were isolated and identified by classical microbiology and mass spectrometry. Antibiotic resistance and adherence profiles were determined. Finally, resistance (mecA/SCCmec) and virulence (icaA and icaD) genes were detected in the Gram-positive population. The results showed that blepharitis was the most prevalent condition in the study population. A MALDI-TOF analysis revealed that Staphylococcus and Pseudomonas genus were the most prevalent as causal agents of infection. Resistances to β-lactams were detected of 44 to 100%, followed by clindamycins, aminoglycosides, folate inhibitors, and nitrofurans. A multiple correspondence analysis showed a relationship between mecA genotype and β-lactams resistance. The identification of SCCmecIII and SCCmecIV elements suggested community and hospital sources of infection. Finally, the coexistence of icaA+/icaD+/mecA(SCCmecIII) and icaA+/icaD+/mecA(SCCmecIV) genotypes was detected in S. aureus. The identification of resistant and virulent isolates highlights the importance of developing protocols that address the timely diagnosis of ocular infections. Herein, implications for the failure of antimicrobial therapy in the treatment of ocular infections in susceptible patients are analysed and discussed.

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